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Table 2 Crude Mortality Rates (CMR) and Standardized Mortality Ratios (SMR) for partner participants, by Key Strata

From: Causes and risk factors of death among people who inject drugs in Indonesia, Ukraine and Vietnam: findings from HPTN 074 randomized trial

Variable

No. of Deaths

Person-Years

CMR per 100PY [95% CI]a

SMR [95% CI]b

Overall

19

910.88

2.1 [1.3, 3.3]

5.8 [3.5, 9.1]

Gender

 Female

2

110.15

1.8 [0.2, 6.6]

11.0 [1.3, 39.6]

 Male

17

800.73

2.1 [1.2, 3.4]

5.5 [3.2, 8.9]

Study site

 Indonesia

3

193.87

1.5 [0.3, 4.5]

7.9 [1.6, 23.0]

 Ukraine

12

364.21

3.3 [1.7, 5.8]

6.2 [3.2, 10.9]

 Vietnam

4

352.80

1.1 [0.3, 2.9]

4.2 [1.1, 10.7]

Study site by Gender

 Indonesia – Female

0

19.13

0.0 [0.0, 19.3]

0.0 [0.0, 143.0]

 Indonesia – Male

3

174.74

1.7 [0.4, 5.0]

8.4 [1.7, 24.7]

 Ukraine – Female

2

81.68

2.4 [0.3, 8.9]

13.4 [1.6, 48.6]

 Ukraine – Male

10

282.53

3.5 [1.7, 6.5]

5.6 [2.7, 10.4]

 Vietnam – Female

0

9.34

0.0 [0.0, 39.5]

0.0 [0.0, 473.6]

 Vietnam – Male

4

343.46

1.2 [0.3, 3.0]

4.2 [1.2, 10.8]

Study arm

 SOC

18

694.68

2.6 [1.5, 4.1]

7.3 [4.3, 11.6]

 Intervention

1

216.20

0.5 [0.0, 2.6]

1.2 [0.0, 7.0]

Alcohol use in the past 3 months

 Non-hazardous alcohol use

10

604.48

1.7 [0.8, 3.0]

5.0 [2.4, 9.1]

 Hazardous alcohol use

9

306.40

2.9 [1.3, 5.6]

7.2 [3.3, 13.7]

Injecting opioids in the past 3 months

 No

0

146.97

0.0 [0.0, 2.5]

0.0 [0.0, 9.6]

 Yes

19

763.91

2.5 [1.5, 3.9]

6.6 [4.0, 10.3]

Injecting stimulants in the past 3 months

 No

16

770.29

2.1 [1.2, 3.4]

6.2 [3.5, 10.0]

 Yes

3

140.59

2.1 [0.4, 6.2]

4.5 [0.9, 13.1]

Injecting other drugs in the past 3 months

 No

13

734.08

1.8 [0.9, 3.0]

5.5 [2.9, 9.4]

 Yes

6

176.80

3.4 [1.3, 7.4]

6.8 [2.5, 14.7]

No injecting drug use in the past 3 months

 No

19

774.97

2.5 [1.5, 3.8]

6.5 [3.9, 10.2]

 Yes

0

135.91

0.0 [0.0, 2.7]

0.0 [0.0, 11.0]

Injecting Polydrug use in the past 3 months

 No

11

663.46

1.7 [0.8, 3.0]

5.4 [2.7, 9.7]

 Yes

8

247.42

3.2 [1.4, 6.4]

6.5 [2.8, 12.8]

Non-injecting opioids use in the past 3 months

 No

18

850.93

2.1 [1.3, 3.3]

5.9 [3.5, 9.3]

 Yes

1

59.95

1.7 [0.0, 9.3]

5.3 [0.1, 29.4]

Non-injecting stimulants use in the past 3 months

 No

14

631.86

2.2 [1.2, 3.7]

5.7 [3.1, 9.6]

 Yes

5

279.03

1.8 [0.6, 4.2]

6.3 [2.0, 14.6]

Non-injecting other drug use in the past 3 months

 No

8

391.92

2.0 [0.9, 4.0]

5.9 [2.5, 11.6]

 Yes

11

518.97

2.1 [1.1, 3.8]

5.8 [2.9, 10.4]

No non-injecting drug use in the past 3 months

 No

13

637.99

2.0 [1.1, 3.5]

5.8 [3.1, 9.9]

 Yes

6

272.89

2.2 [0.8, 4.8]

6.0 [2.2, 13.0]

Non-injecting polydrug use in the past 3 months

 No

15

696.48

2.2 [1.2, 3.6]

5.7 [3.2, 9.4]

 Yes

4

214.40

1.9 [0.5, 4.8]

6.4 [1.8, 16.5]

OAT status

 ever used

5

460.78

1.1 [0.4, 2.5]

3.1 [1.0, 7.3]

 OAT naïve

14

450.10

3.1 [1.7, 5.2]

8.4 [4.6, 14.1]

  1. a Based upon person-time between study enrollment and either the date of death or last follow-up visit. For time-varying covariates, the amount of person time was determined based on the value at the end of each follow-up interval. Exact confidence intervals were calculated using the Poisson distribution
  2. b Calculated as the observed number of deaths divided by the number of deaths that would be expected according to the data from the Global Burden of Disease Study, separately for males and females, each 5-year age category, and each country