Fig. 1

Schematic descriptions of the models for the development of antimicrobial resistance in Neisseria gonorrhoeae. Panel A, single-step, panel B, multiple steps to resistance. Compartment S corresponds to susceptible; compartments I₁ to I_k correspond to infected with increasingly resistant strains of N. gonorrhoeae. β is the transmission rate, ν is the rate of spontaneous recovery, τ is the rate of recovery due to treatment, μ is the probability of developing resistance (or one step of resistance for the multi-step model) upon treatment, and ϵ is the reduction of treatment efficacy for resistant strains. The function p(t) corresponds to the probability that treatment at time t includes the antibiotic of interest