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Table 1 Clinical characteristics and drugs used in the successful and unsuccessful treatment outcome groups

From: Development and validation of a prediction model for unsuccessful treatment outcomes in patients with multi-drug resistance tuberculosis

Variables

Total

(n = 446)

Success

(n = 299)

UTO

(n = 147)

P

Health education a

225 (50.4)

168 (56.2)

57 (38.8)

< 0.001

Sex a

   

< 0.001

female

134 (30.0)

109 (36.5)

25 (17)

 

male

312 (70.0)

190 (63.5)

122 (83)

 

Age(years)b

38.1 ± 15.0

34.9 ± 13.8

44.7 ± 15.4

< 0.001

Address a

   

0.653

Xi’an

189 (42.4)

124 (41.5)

65 (44.2)

 

Other regions

257 (57.6)

175 (58.5)

82 (55.8)

 

BMI(kg/m2)b

20.3 ± 2.8

20.3 ± 2.8

20.1 ± 2.9

0.509

Marriage a

   

0.03

married

292 (65.5)

185 (61.9)

107 (72.8)

 

single

154 (34.5)

114 (38.1)

40 (27.2)

 

Grade of smear a

   

0.007

0

182 (40.8)

137 (45.8)

45 (30.6)

 

1

106 (23.8)

72 (24.1)

34 (23.1)

 

2

53 (11.9)

31 (10.4)

22 (15)

 

3

49 (11.0)

30 (10)

19 (12.9)

 

4

56 (12.6)

29 (9.7)

27 (18.4)

 

Drug sensitivity test

    

Fluoroquinolones a

   

0.448

sensitive

336 (75.3)

229 (76.6)

107 (72.8)

 

resistant

110 (24.7)

70 (23.4)

40 (27.2)

 

Injectable agents a

   

0.902

sensitive

430 (96.4)

289 (96.7)

141 (95.9)

 

resistant

16 ( 3.6)

10 (3.3)

6 (4.1)

 

Cavity a

285 (63.9)

195 (65.2)

90 (61.2)

0.471

Lung Lesions (field) b

3.1 ± 1.8

2.8 ± 1.7

3.8 ± 1.8

< 0.001

Treatment history a

   

< 0.001

New case

236 (52.9)

176 (58.9)

60 (40.8)

 

Previously treated

210 (47.1)

123 (41.1)

87 (59.2)

 

Diabetes mellitus a

70 (15.7)

35 (11.7)

35 (23.8)

0.002

Drugs used in regimen

    

Fluoroquinolones a

373 (83.6)

255 (85.3)

118 (80.3)

0.227

Linezolid a

113 (25.3)

74 (24.7)

39 (26.5)

0.771

Cycloserine a

332 (74.4)

228 (76.3)

104 (70.7)

0.255

Clofazimine a

36 ( 8.1)

22 (7.4)

14 (9.5)

0.546

Ethambutol a

181 (40.6)

124 (41.5)

57 (38.8)

0.658

Pyrazinamid a

439 (98.4)

294 (98.3)

145 (98.6)

1

injectable agents a

431 (96.6)

290 (97)

141 (95.9)

0.582

Prothionamide a

406 (91.0)

271 (90.6)

135 (91.8)

0.809

P-aminosalicylate a

30 ( 6.7)

16 (5.4)

14 (9.5)

0.146

  1. a, n (%),b, Mean ± SD. UTO, unsuccessful treatment outcome