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Table 1 The variables of training and validation cohort

From: Development and validation of a nomogram for predicting severe respiratory syncytial virus-associated bronchiolitis

 

Patients (n = 325)

Training group (n = 227)

Validation group (n = 98)

P

Age, monthsb

5(2–10)

5(2–10)

5(3–9.3)

0.936

Sex, male/female

206/119

146/81

60/38

0.595

weight at admission, kgb

7.8(6.3–9.5)

7.7(6.2–9.6)

7.8(6.5–9.4)

0.836

Region, rural/urban

110/215

79/148

31/67

0.580

preterm birth, n(%)

36(11.1%)

27(11.9%)

9(9.2%)

0.475

cesarean section, n(%)

171(52.6%)

121(53.3%)

50(51%)

0.705

history of birth asphyxia, n(%)

6(1.8%)

5(2.2%)

1(1%)

0.467

birth weight, kgb

3.3(3.0–3.6)

3.3(3.0–3.6)

3.3(2.9–3.7)

0.664

non-breastfeeding, n(%)

173(53.2%)

124(54.6%)

49(50%)

0.443

underlying diseases, n(%)

16(4.9%)

12(5.3%)

4(4.1%)

0.645

history of wheezing, n(%)

20(6.2%)

16(7.0%)

4(4.1%)

0.307

history of eczema, n(%)

143(44%)

106(46.7%)

37(37.8%)

0.136

Fever, n(%)

178(54.8%)

128(56.4%)

50(51%)

0.372

Length of cough, daysb

4(3–6)

4(3–6)

4(3–8)

0.681

Length of wheezing, daysb

1(0–3)

1(0–3)

2(0–4)

0.017

Outpatient use of antibiotics, n(%)

247(76%)

168(74%)

79(80.6%)

0.201

Outpatient use of glucocorticoids, n(%)

86(26.5%)

57(25.1%)

29(29.6%)

0.401

Breath rateb

45(40–51)

45(40–51)

44(40–51.5)

0.845

Three concave signs, n(%)

98(30.2%)

66(29.1%)

32(32.7%)

0.579

Abnormal lung auscultation, n(%)

322(99.1%)

224(98.7%)

98(100%)

0.253

Abnormal radiological findings, n(%)

198(60.9%)

141(62.1%)

57(58.2%)

0.503

Length of stay, daysb

6(5–7)

6(5–7)

5(4–7)

0.303

WBC, × 109/La

8.8 ± 3.3

8.6 ± 3.3

9.3 ± 3.2

0.105

N%a

32.2 ± 15.4

33.1 ± 15.6

29.9 ± 14.8

0.078

L%a

57.2 ± 15.1

56.1 ± 15.1

59.5 ± 14.8

0.063

E%b

0.0(0.0–2.0)

0.0(0.0–2.0)

0.0(0.0–2.0)

0.540

Hb, g/Lb

115(106–121)

114(105–121)

111(104.5–119)

0.166

CRP, mg/Lb

2.5(2.5–2.7)

2.5(2.5–3.0)

2.5(2.5–2.5)

0.384

PCT, ng/mlb

0.07(0.05–0.10)

0.07(0.05–0.10)

0.07(0.05–0.10)

0.265

IL-6, pg/mlb

7.6(4.4–13.4)

7.7(4.4–12.4)

7.1(4.2–15.7)

0.985

La, mol/Lb

3.2(2.6–4.0)

3.2(2.6–3.9)

3.3(2.5–4.3)

0.786

AST, U/Lb

44(36–59)

43.0(34.0–58)

47(38.8–63)

0.038

ALT, U/Lb

22(17.0–34.0)

22.0(16–32)

24.5(18.0–37.3)

0.057

CK, U/Lb

103.0(74–146)

104(78–146)

100.5(69.5–146)

0.543

CKMB, Ub/L

12(7–23)

12(7.0–23)

12(7.0–24.3)

0.663

LDH, U/Lb

398((340.5–493.5)

392(337–482)

415.5(346.3–515)

0.079

IgE, IU/Lb

12.9(3.8–40.6)

11.5(3.3–38.7)

12.4(4.5–47.4)

0.851

  1. Abbreviations: WBC White blood cell, N Peripheral neutrophils, L Peripheral lymphocytes, E Peripheral eosinophils, Hb Hemoglobin, CRP C-reactive protein, PCT Procalcitonin, IL-6 Interleukin (IL)-6, La Lactic acid, AST Aspartate aminotransferase, ALT Alanine aminotransferase, CK Creatine kinase, CKMB Creatine kinase isomer-MB, LDH Lactic dehydrogenase, IgE Immunoglobulin E
  2. aMean ± SD
  3. bMedian (IQR)