Table 1 Baseline characteristics of critically ill patients suffering from sepsis

Age (years)

68 (57–79)

66 (55–79)

62 (51–73)

68 (51–81)

55 (46–65)

65 (51–77)

< 0.001

Male

50% (7,097)

48% (135)

54% (995)

49% (351)

43% (63)

55% (454)

0.045

BMI

27 (23–33)

25 (21–28)

27 (22–33)

26 (22–30)

28 (24–37)

27 (23–31)

< 0.001

SOFA

5 (3–8)

6 (3–8)

6 (4–9)

5 (3–8)

6 (4–10)

6 (3–9)

< 0.001

APACHE

65 (50–82)

63 (45–82)

66 (49–85)

65 (49–83)

69 (52–90)

66 (47–86)

0.16

Lactate on admission [mmol/L]

1.9 (1.2–3.2)

2.3 (1.5–3.9)

2.0 (1.2–3.7)

2.0 (1.3–3.7)

1.9 (1.1–3.4)

2.0 (1.3–3.5)

0.010

Lactate on admission > 2 mmol/L

42% (3,732)

51% (90)

45% (500)

43% (180)

43% (46)

46% (250)

0.039

Serum creatinine on admission [mg/dL]

1.3 (0.9–2.3)

1.2 (0.8–2.3)

1.7 (1.0–3.5)

1.2 (0.8–2.0)

1.3 (0.7–2.9)

1.3 (0.8–2.3)

< 0.001

Hemoglobin (g/dL)

10.3 (8.9–11.8)

10.3 (8.7–11.8)

9.7 (8.3–11.1)

10.2 (8.8–11.6)

10.1 (8.2–11.6)

10.3 (8.9–11.7)

< 0.001

Platelets × 1000

183.0 (127.0–254.0)

170.5 (114.0–235.0)

186.0 (124.0–258.0)

178.0 (118.0–250.0)

168.5 (84.0–227.0)

176.0 (119.0–245.0)

< 0.001

WBC × 1000

12.9 (8.5–18.6)

11.5 (7.6–17.6)

12.5 (8.2–18.9)

12.2 (8.0–18.2)

14.6 (8.7–21.1)

12.6 (8.2–18.5)

0.056

Primary focus

< 0.001

 GI

12% (1,759)

14% (38)

8% (157)

13% (93)

14% (20)

14% (116)

 Cutaneous/soft tissue

8% (1,184)

9% (25)

9% (173)

6% (43)

14% (21)

6% (50)

 Gynecologic

0% (33)

0% (1)

0% (8)

1% (8)

1% (1)

1% (5)

 Other

6% (787)

7% (20)

10% (189)

12% (86)

3% (5)

8% (64)

 Pulmonary

39% (5,505)

34% (95)

33% (608)

28% (200)

34% (50)

36% (301)

 Renal/UTI (including bladder)

23% (3,315)

20% (56)

24% (436)

28% (200)

26% (38)

25% (208)

 Unknown

11% (1,541)

16% (45)

15% (281)

12% (87)

8% (11)

10% (86)