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Table 1 Demographic and clinical characteristics of enrolled patients with community-acquired pneumonia requiring hospitalization

From: Identification of priority pathogens for aetiological diagnosis in adults with community-acquired pneumonia in China: a multicentre prospective study

 

All cases

Virus positive

Bacterium positive

Negative detection

P-value (virus vs. bacterium)

P-value (virus vs. negative)

Total

3403

654a

948b

1349

  

Age group, no. (%)

-

     

 14–24 yrs

231 (6.79)

30 (4.59)

103 (10.86)

71 (5.26)

< 0.001

0.517

 25–44 yrs

795 (23.36)

129 (19.72)

282 (29.75)

265 (19.64)

< 0.001

0.966

 45–64 yrs

1161 (34.12)

228 (34.86)

261 (27.53)

523 (38.77)

0.002

0.090

 ≥ 65 yrs

1216 (35.73)

267 (40.83)

302 (31.86)

490 (36.32)

< 0.001

0.051

Sex (male/female)

2060/1343

397/257

547/401

 

0.23

0.421

Season, no. (%)

-

     

 Spring

799 (23.48)

165 (25.23)

214 (22.57)

326 (24.17)

0.219

0.604

 Summer

753 (22.13)

102 (15.60)

253 (26.69)

308 (22.83)

< 0.001

< 0.001

 Autumn

911 (26.77)

151 (23.09)

290 (30.59)

350 (25.95)

0.001

0.166

 Winter

940 (27.62)

236 (36.09)

191 (20.15)

365 (27.06)

< 0.001

< 0.001

Median duration of illness (days)

7 (4–11)

7 (4–10)

7 (3–10)

 

0.167

 

Died in hospital, no. (%)

66 (1.94)

16 (2.45)

22 (2.32)

17 (1.26)

0.871

0.050

Severe pneumonia, no. (%)

462 (13.58)

121 (18.50)

123 (12.97)

151 (11.19)

0.002

< 0.001

ICU admission, no. (%)

317 (9.32)

84 (12.84)

88 (9.28)

104 (7.71)

0.024

< 0.001

Sepsis, no. (%)

116 (3.41)

26 (3.98)

37 (3.90)

27 (2.00)

0.941

0.010

Noninvasive ventilation

374 (10.99)

94 (14.37)

90 (9.49)

138 (10.23)

0.003

0.007

Invasive ventilation

165 (4.85)

37 (5.66)

57 (6.01)

48 (3.56)

0.766

0.029

Underlying diseases, no. (%)

-

     

 Diabetes

238 (6.99)

46 (7.03)

64 (6.75)

94 (6.97)

0.826

0.957

 Congestive heart failure

226 (6.64)

61 (9.33)

48 (5.06)

84 (6.23)

0.001

0.012

 Cerebral vascular disease

164 (4.82)

34 (5.20)

45 (4.75)

67 (4.97)

0.681

0.824

 COPD

99 (2.91)

24 (3.67)

19 (2.00)

41 (3.04)

0.043

0.455

 Chronic liver disease

79 (2.32)

19 (2.91)

23 (2.43)

29 (2.15)

0.555

0.300

 Chronic kidney disease

56 (1.65)

13 (1.99)

16 (1.69)

17 (1.26)

0.658

0.209

 Bronchiectasis

37 (1.09)

9 (1.38)

13 (1.37)

12 (0.89)

0.993

0.316

Clinical symptoms, no. (%)

-

     

 Cough

3005 (88.30)

593 (90.67)

842 (88.82)

1153 (85.47)

0.233

0.001

 Sputum

2552 (74.99)

502 (76.76)

715 (75.42)

991 (73.46)

0.538

0.112

 Dyspnoea

442 (12.99)

99 (15.14)

98 (10.34)

174 (12.90)

0.004

0.171

 Chest pain

437 (12.84)

78 (11.93)

109 (11.50)

189 (14.01)

0.793

0.198

 Tachypnea

398 (11.70)

90 (13.76)

94 (9.92)

151 (11.19)

0.018

0.098

 Short breath

396 (11.64)

99 (15.14)

74 (7.81)

185 (13.71)

< 0.001

0.392

 Fatigue

238 (6.99)

43 (6.57)

62 (6.54)

97 (7.19)

0.978

0.612

 Chills

232 (6.82)

60 (9.17)

53 (5.59)

90 (6.67)

0.006

0.046

 Sore throat

220 (6.46)

37 (5.66)

85 (8.97)

55 (4.08)

0.014

0.113

 Headache

176 (5.17)

31 (4.74)

66 (6.96)

66 (4.89)

0.067

0.882

 Runny nose

149 (4.38)

34 (5.20)

48 (5.06)

37 (2.74)

0.904

0.005

 Haemoptysis

144 (4.23)

33 (5.05)

39 (4.11)

60 (4.45)

0.376

0.551

 Myalgia

130 (3.82)

29 (4.43)

32 (3.38)

50 (3.71)

0.276

0.433

 Nausea

90 (2.64)

21 (3.21)

27 (2.85)

32 (2.37)

0.675

0.273

 Diarrhoea

33 (0.97)

10 (1.53)

8 (0.84)

9 (0.67)

0.201

0.062

 Arthralgia

30 (0.88)

7 (1.07)

6 (0.63)

14 (1.04)

0.337

0.947

 Abdominal pain

27 (0.79)

6 (0.92)

9 (0.95)

8 (0.59)

0.948

0.405

 Oliguria

11 (0.32)

4 (0.61)

2 (0.21)

4 (0.30)

0.233

0.287

 Bleeding

9 (0.26)

3 (0.46)

2 (0.21)

3 (0.22)

0.404

0.399

Laboratory findings on admission, no. (%)

-

     

 Temperature ≥ 38·0 °C

1502 (44.14)

310 (47.40)

422 (44.51)

554 (41.07)

0.254

0.007

 Elevated WBC count (> 10 × 10^9/L)

846 (28.01)c

163 (27.30)d

243 (30.04)e

197 (14.60)

0.264

0.079

 ALT > 40, U/L

669 (22.17)f

135 (22.73)g

163 (20.10)h

318 (23.57)

0.234

0.596

 BUN > 7, mmol/L

623 (20.88)i

137 (23.26)j

163 (20.25)k

292 (21.65)

0.177

0.005

 PaO2/FiO2 < 300, mmHg

2745 (98.95)l

492 (90.61)m

671 (87.26)n

240 (17.79)

0.059

< 0.001

  1. a Virus-positive patients are those with one or more positive detection results for viruses, not including those with co-detection of viruses and bacteria
  2. b Bacterium-positive patients are those with one or more positive detection results for bacteria, not including those with co-detection of bacteria and viruses
  3. c Information on WBC count was missing for 383 patients; therefore, the total number for this item was 3,020
  4. d The total number for this item was 597
  5. e The total number for this item was 809
  6. f Information on ALT was missing for 386 patients; therefore, the total number for this item was 3,017
  7. g The total number for this item was 594
  8. h The total number for this item was 811
  9. i Information on BUN was missing for 419 patients; therefore, the total number for this item was 2,984
  10. j The total number for this item was 589
  11. k The total number for this item was 805
  12. l Information on PaO2/FiO2 was missing for 629 patients; therefore, the total number for this item was 2,774
  13. m The total number for this item was 543
  14. n The total number for this item was 769
  15. ICU, intensive care unit; COPD, chronic obstructive pulmonary disease; WBC, white blood cell, elevated white blood cell (WBC) count was defined as greater than 10 × 109 cells per L for adults; ALT, alanine aminotransferase; BUN, blood urea nitrogen
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BMC Infectious Diseases

ISSN: 1471-2334

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