Table 2 HIV Viral load monitoring cascade and outcomes

1. Cascade of viral load testing

 a. Number of PLHIV

4,454

 b. PLHIV with blood sample taken for HVL testing

4,238/4,454 (95%)

 c. PLHIV with a HVL result reported in the medical records

4,177/4,238 (99%)

  i. Overall number of HVL test results

12,512

  ii. HVL tests per person, median (IQR)

3 (2–4)

2. Results of first HVL measurement

 a. HVL < 1000 copies/mL (suppressed HVL)

3,683/4,177 (88%)

  i. HVL 100–999 copies/mL (Low-level viremia (LLV))

371/4,177 (9%)

  ii. HVL < 100 copies/mL

3,312/4,177 (79%)

 b. HVL ≥ 1000 copies/mL (unsuppressed HVL)

494/4,177 (12%)

3. Cascade of care for PLHIV with HVL < 100 copies/mL, n = 3,312

 a. Number with follow-up HVL

2,876/3,312 (87%)

 b. Median time to follow-up HVL, n = 2,876

12.0 months (11.8–13.2)

 c. HVL < 100 copies/mL

2,653/2,876 (92%)

 d. LLV

132/2,876 (5%)

 e. Unsuppressed HVL

91/2,876 (3%)

4. Cascade of care for PLHIV with LLV, n = 371

 a. Number with follow-up HVL

327/371 (88%)

 b. Median time to follow-up HVL, n = 327

9.0 months (6.0–12.2)

 c. HVL < 100 copies/mL

267/327 (82%)

 d. Persistent LLV

41/327 (13%)

 e. Unsuppressed HVL

19/327 (6%)

5. Cascade of care for PLHIV with unsuppressed HVL, n = 494

 a. No follow-up HVL

69/494 (14%)

 b. Virologic failure (VF)

158/425 (37%)

 c. Suppressed HVL

267/425 (63%)

  i. HVL < 100 copies/mL

216/425 (51%)

  ii. LLV

51/425 (12%)

 d. Months from date of unsuppressed HVL to date of follow-up HVL, median (IQR), n = 425

6.4 months (5.1 – 9.0)

  i. ≤ 4 months

102 (24%)

  ii. 5—6 months

136 (32%)

  iii. 7—9 months

114 (27%)

  iv. 10—12 months

40 (9%)

  v. ≥ 13 months

33 (8%)

 e. Switched to second line ART among suppressed follow up HVL, n = 267

  i. Already on second line ART at unsuppressed HVL

109/267 (41%)

  ii. Switched to second line ART by follow-up HVL

11/267 (4%)

 f. Outcomes for those with VF, n = 158

  i. Already on second line ART at follow-up HVL

103/158 (65%)

  ii. Of those still on first-line, switched to second line ART

32/55 (58%)

   - Months from date of follow-up HVL to date of second line ART switch, n = 32

7.7 months (4.7–12.7)

  iii. No switch to second line despite VF

23/55 (42%)

   -Had a third HVL

16/23 (26%)

    i. Unsuppressed HVL

3/16 (19%)

    ii. Suppressed HVL

13/16 (81%)

   - Months from date of follow-up HVL to date of status (database censor date/LTFU/death), n = 23

16.4 months (9.1–25.8)

   - ≤ 4 months since follow-up HVL

5/23 (22%)

   - Active in care

14/23 (61%)

   - LTFU

6/23 (26%)

   - Died

2/23 (9%)

   - Transfer out

1/23 (4%)