Fig. 4

Changes in viral RNA shedding in patients with influenza A and B after treatment. a and e Patients treated with baloxavir; b and f, patients treated with laninamivir; c and g, patients treated with oseltamivir; d and h, patients treated with zanamivir. The red solid line in each figure represents the paired samples that showed potential infectivity in the second visit collected between 5 to 13th days after symptom onset in the patient. The cut-off value for viral RNA shedding in influenza A and B was 2.628 log₁₀ copies/µL and 1.886 log₁₀ copies/µL, respectively. The solid gray line represents those with negative potential infectivity below the cut-off. The vertical red dotted line represents the fifth day after symptom onset. The red numeric numbers represent the rate of positive infectivity in the upper part and the corresponding percentage in the lower part