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Table 1 Perceived Importance of Factors Affecting Testing or Diagnosis

From: Evaluation of under-testing and under-diagnosis of tick-borne encephalitis in Germany

Criteria

How can it impact the diagnostic process?

Perceived impact

Clinical presentations

The decision to run some specific tests is always driven by the clinical symptoms

1

Patients medical, geographic, or past activities history

Physicians mentioned that travel activity or being outdoors has some influence

2

Previous laboratory tests

Most relevant tests are carried out within the clinic. They usually do not re-do a test ordered by another department, except if there is a good reason

3

Time of a year (seasonality)

The seasons in and of themselves have no influence on the test. However, some doctors are more sensitive to TBE; all doctors tend to think of TBE in the warmer seasons when arthropods, such as ticks, are more active, and people are outdoors more often

4

Availability of a test

Availability only plays a minor role, as physicians always have access to an external laboratory, if necessary

4

Costs of tests

Cost also plays a minor role; tests are usually reimbursed. A few mentioned that they do not always order a PCR test because of the cost

4

How soon to receive the result?

Physicians receive most of the test results within 1 day. However, ELISA tests can take up to 4 days

4

Reliability (sensitivity and specificity) of a test

This is not a concern

5

Convenience or access of a test

This is not a concern

5

  1. Each criterion was rated on a scale from 1 (very high impact) to 5 (very low impact). ELISA: enzyme-linked immunoassay; PCR: polymerase chain reaction; TBE: tick-borne encephalitis