Table 4 Laboratory values of COVID-19 patients at baseline and association with a severe disease progression based on patients from the LEOSS cohort
| Â | Overall | Patients without severe disease course | Patients with severe disease course | Crude RR1 (95% CI) | Multivariable regression RR (95% CI)2 |
|---|---|---|---|---|---|
Patients, n | 6672 | 5242 | 1430 | Â | Â |
Lab values > ULN, n (%) | |||||
 AST | 36.8% (1449/3935) | 34.0% (1060/3121) | 47.8% (389/814) | 1.57 (1.39–1.77) | 1.54 (1.37–1.73) |
 ALT | 23.4% (1015/4345) | 23.0% (787/3429) | 24.9% (228/916) | 1.09 (0.95–1.24) | 1.29 (1.14–1.47) |
 GGT | 38.1% (1539/4042) | 35.4% (1129/3188) | 48.0% (410/854) | 1.50 (1.33–1.69) | 1.47 (1.31–1.65) |
 Bilirubin | 6.9% (274/3980) | 5.5% (171/3131) | 12.1% (103/849) | 1.87 (1.58–2.20) | 1.55 (1.32–1.82) |
 Lipase | 19.1% (513/2679) | 18.5% (395/2132) | 21.6% (118/547) | 1.16 (0.97–1.39) | 1.13 (0.95–1.35) |
 Troponin T | 42.2% (1001/2371) | 35.5% (662/1863) | 66.7% (339/508) | 2.75 (2.33–3.24) | 1.95 (1.60–2.38) |
 Creatinine | 31.1% (1524/4906) | 25.9% (1002/3865) | 50.1% (522/1041) | 2.23 (2.01–2.48) | 1.67 (1.50–1.86) |
 Urea | 26.9% (1126/4191) | 21.1% (702/3327) | 49.1% (424/864) | 2.62 (2.34–2.94) | 1.86 (1.64–2.10) |
 LDH | 62.5% (2687/4297) | 58.5% (1972/3372) | 77.3% (715/925) | 2.04 (1.77–2.35) | 1.80 (1.56–2.06) |
 D-Dimer | 68.7% (1855/2701) | 64.7% (1370/2119) | 83.3% (485/582) | 2.28 (1.86–2.79) | 1.85 (1.51–2.26) |
 Ferritin | 53.4% (1190/2229) | 49.4% (873/1768) | 68.8% (317/461) | 1.92 (1.61–2.30) | 1.74 (1.46–2.07) |
CRP ≥ 30 mg/l | 51.4% (2522/4907) | 45.0% (1738/3859) | 74.8% (784/1048) | 2.81 (2.47–3.19) | 2.30 (2.03–2.62) |
PCT > 0.5 ng/ml | 14.2% (446/3131) | 9.6% (230/2395) | 29.3% (216/736) | 2.50 (2.21–2.83) | 2.21 (1.95–2.50) |
Lymphocytes < 800/µl | 38.0% (1431/3765) | 33.1% (990/2993) | 57.1% (441/772) | 2.17 (1.91–2.47) | 1.79 (1.58–2.03) |
Leukocytes < 4000/µl | 15.5% (773/4980) | 16.0% (630/3932) | 13.6% (143/1048) | 0.94 (0.80–1.11) | 1.05 (0.90–1.22) |
Leukocytes ≥ 12,000/µl | 9.1% (454/4980) | 7.3% (286/3932) | 16.0% (168/1048) | 1.88 (1.64–2.16) | 1.70 (1.49–1.94) |
Neutrophils < 2000/µl | 13.5% (498/3697) | 14.3% (420/2941) | 10.3% (78/756) | 0.81 (0.65–1.01) | 0.93 (0.75–1.15) |
Neutrophils ≥ 9000/µl | 9.3% (343/3697) | 7.3% (216/2941) | 16.8% (127/756) | 1.92 (1.64–2.25) | 1.68 (1.44–1.96) |