Candida bloodstream infection among children hospitalised in three public-sector hospitals in the Metro West region of Cape Town, South Africa

Table 3 Distribution and antifungal susceptibility results of Candida species causing Candida bloodstream infection

Candida species	Antifungal susceptibility results
Candida species		Fluconazole	Amphotericin B	Echinocandins	Voriconazole
C. albicans (n = 38)	No. isolates tested	38	38	35	38
C. albicans (n = 38)	No. (%) Susceptible	38(100)	38 (100)	35 (100)	38 (100)
C. parapsilosis (n = 24)	No. isolates tested	24	24	23	24
C. parapsilosis (n = 24)	No. (%) Susceptible	20 (83)^d	24 (100)	23 (100)	22 (92)^e
C. glabrata^a (n = 4)	No. isolates tested	2	4	3	0
C. glabrata^a (n = 4)	No. (%) Susceptible	–	4 (100)	3 (100)	–
C. tropicalis (n = 6)	No. isolates tested	6	6	6	6
C. tropicalis (n = 6)	No. (%) Susceptible	6 (100)	6 (100)	6 (100)	6 (100)
C. krusei^b (n = 3)	No. isolates tested	3	3	2	3
C. krusei^b (n = 3)	No. (%) Susceptible	0 (0)	3 (100)	2 (100)	3 (100)
C. lusitaniae^c (n = 1)	No. isolates tested	1	1	1	0
C. lusitaniae^c (n = 1)	No. (%) Susceptible	–	–	–	–
C. magnolae^c (n = 1)	No. isolates tested	0	0	0	0
C. magnolae^c (n = 1)	No. (%) Susceptible	–	–	–	–

No., number
^aC. glabrata: There is no susceptibility category for fluconazole, or interpretive criteria for voriconazole
^bC. krusei: This organism is assumed to be intrinsically resistant to fluconazole
^cThere are no interpretive criteria for these organisms
^dThree isolates (13%) were categorised as fluconazole resistant, and one isolate (4%) categorised as susceptible-dose dependent according to Clinical and Laboratory Standards Institute guidelines, refer reference 17
^eTwo isolates (8%) were categorised as voriconazole resistant according to Clinical and Laboratory Standards Institute guidelines, refer reference [17]

ISSN: 1471-2334