Table 1 Comparison of the sensitivity, specificity and positive rate of QFT-PLUS and QFT-GIT
Studies (n) | Participants (n) | QFT-PLUS positive | I2 (%) | QFT-GIT positive | I2 (%) | RD-test | I2 (%) | |
|---|---|---|---|---|---|---|---|---|
Active TB | 12 | 1004 | 0.886 (0.812–0.944) | 87 | 0.879 (0.802–0.939) | 87 | 0.01 (− 0.02–0.03) | 0 |
Populations with very low risk of TB exposure | 5 | 482 | 0.987 (0.961–0.999) | 65 | 0.996 (0.984–1.000) | 28 | 0.00 (− 0.02–0.01) | 0 |
High-risk populations | 18 | 4617 | 0.235 (0.154–0.328) | 97 | 0.228 (0.144–0.323) | 97 | 0.02 (0.01–0.03) | 0 |
Recent contacts | 7 | 1391 | 0.311 (0.185–0.453) | 97 | 0.286 (0.167–0.423) | 97 | 0.02 (0.00–0.05) | 0 |
Immunocompromised patients | 4 | 850 | 0.317 (0.107–0.578) | 95 | 0.304 (0.090–0.578) | 96 | 0.01 (− 0.02–0.05) | 0 |
With possibility of contact | 6 | 2147 | 0.108 (0.039–0.205) | 98 | 0.119 (0.027–0.264) | 98 | 0.02 (0.00–0.03) | 37 |
With possibility of immunosuppression | 1 | 229 | NA | NA | NA | NA | 0.03 (− 0.05–0.12) | 0 |