Table 2 Neurological sequelae

Schleede L, 2012

32

18 (56.2%)

Abnormal movement patterns, 8

Cranial nerve palsies, 6

Tetra/hemiparesis, 6

Aphasia, 4

Memory impairment, 2

Psychiatric symptoms, 2

Hyperreflexia, 2

Seizures, 1

Eye movement disorder, 1

Low muscle tone, 1

Sensory disturbance, 1

Arreflexia, 1

With disability: 35

 Seizures: 1 (2.8%)

 Motor disability: 15 (42.8%)

 Visual impairment: 1 (2.8%)

 Mental disability: 8 (22.8%)

 Others: 10 (28.5%)

?

Elbers JM, 2007

16

10 (62.5%)

Seizures, 7

Global developmental delays, 4

Residual hemiplegia, 2

With disability: 13

 Seizures: 7 (53.8%)

 Motor disability: 2 (15.3%)

 Visual impairment: 0

 Mental disability: 4 (30.7%)

 Others: 0

?

Yoshinori I, 1998

24

17 (70.8%)

Mildly disabled (able to perform everyday activities but hampered by neurological defects), 3

Moderately disabled (does not require supportive care, but neurological defects influence daily life), 6

Severely disabled (requires supportive care), 8

With disability: 17

 Seizure: ?

 Motor disability: ?

 Visual impairment: ?

 Mental disability: ?

 Others: ?

2

Chen T, 2018

15

10 (66.6%)

Irritability, 2

Trouble concentrating 5,

Memory impairment, 4

Limb paralysis, 3

Ataxia, 3

Speech disorders, 4

Seizures, 4

With disability: 25

 Seizures: 4 (16%)

 Motor disability: 6 (24%)

 Visual impairment: 0

 Mental disability: 15 (60%)

 Others: 0

2

Kumar R, 2018

23

7 (30.4%)

Seizures, 5

Focal deficit, 1

Altered mental status, 3

With disability: 9

 Seizures: 5 (55.5%)

 Motor disability: 1 (11%)

 Visual impairment: 0

 Mental disability: 3 (33.3%)

 Others: 0

5

Zhang R, 2016

36

13 (36%)

Mild disability (neurological deficit does not affect normal life), 1

Moderate disability (neurological defects affect normal life, but do not require care), 11

Severe disability (cannot take care of themselves, require care), 1

With disability: 13

 Seizure:?

 Motor disability:?

 Visual impairment:?

 Mental disability:?

 Others:?

0

Lahat E, 1999

28

10 (35.7%)

Cognitive dysfunction, 4

Personality change, 4

Speech abnormalities, 2

Motor skill disturbance, 5

Seizures, 4

With disability 19

 Seizures: 4 (21%)

 Motor disability: 5 (26.3%)

 Visual impairment: 0

 Mental disability: 10 (52.6%)

 Others: 0

2

Woźniakowska-Gesicka T, 1996

24

8 (33.3%)

Seizures, 3

Quadriparesis spastic, 1

Encephalopathy and emotional disorders, 4

With disability: 12

 Seizures: 3 (25%)

 Motor disability: 1 (8.3%)

 Visual impairment: 0

 Mental disability: 8 (66.6%)

 Others: 0

?

Ward KN, 2011

19

14 (73.6%)

Developmental cognitive and motor delay, 9

Developmental cognitive delay, 2

Motor system sequelae, 7

Behavioral sequelae, 1

Seizures, 7

Visual sequelae, 3

Autism, 1

Speech alterations, 1

With disability: 40

 Seizures: 7 (17.5%)

 Motor disability: 16 (40%)

 Visual impairment: 3 (7.5%)

 Mental disability: 14 (35%)

 Others: 0

?