Serotype distribution and antimicrobial susceptibility of invasive Streptococcus pneumoniae isolates among adult and elderly population before and after introduction of pneumococcal conjugate vaccine in Casablanca, Morocco

Table 3 Serotype distribution during the pre- and post-vaccine period (early and mature post-vaccine period) in the elderly patients (≥ 60 years)

Serotype	Pre-vaccine period (2007–2010) N = 15			Early post-vaccine period (2011–2014) N = 26			Mature post-vaccine period (2015–2019) N = 12
Serotype	N	%	Cumulative %	N	%	Cumulative %	N	%	Cumulative %
4	2	13.33	13.33	0	0	0	0	0	0
6B	0	0	13.33	1	3.85	3.85	1	8.33	8.33
9V	0	0	13.33	0	0	3.85	0	0	8.33
14	0	0	13.33	1	3.85	7.69	1	8.33	16.67
18C	0	0	13.33	0	0	7.69	0	0	16.67
19F	0	0	13.33	3	11.54	19.23	0	0	16.67
23F	1	6.67	20	0	0	19.23	0	0	16.67
1	0	0	20	2	7.69	26.92	0	0	16.67
5	2	13.33	33.33	0	0	26.92	0	0	16.67
7F	0	0	33.33	0	0	26.92	0	0	16.67
Total PCV-10	5	33.33		7	26.92	P = 0.6692	2	16.67	P = 0.33
3	4	26.67	60	6	23.08	50	0	0	16.67
6A	0	0	60	0	0	50	0	0	16.67
19A	0	0	60	1	3.85	53.85	0	0	16.67
Total PCV-13	9	60		14	53.85	P = 0.7058	2	16.67	P = 0.0255
8	1	6.67	66.66	4	15.38	69.23	1	8.33	25
9N	1	6.67	73.33	0	0	69.23	1	8.33	33.33
12F	1	6.67	80	1	3.85	73.08	0	0	33.33
17F	0	0	80	1	3.85	76.92	0	0	33.33
20	1	6.67	86.66	0	0	76.92	0	0	33.33
23A	0	0	86.66	0	0	0	1	8.33	41.67
22F	1	6.67	93.33	0	0	76.92	0	0	41.67
NVT	1	6.67	100	6	23.08	100	7	58.33	100
Total no PCV-13	6	40		12	46.15	P = 0.7058	10	83.33	P = 0.026

ISSN: 1471-2334