Table 2 Summary of previous cases of Nannizziopsis in literature
Species | Disease | Immunocompromise status | Treatment (and duration, if known) | References | GenBank accesión no. for: |
|---|---|---|---|---|---|
N infrequens | Pneumonia, bronchial wash specimen, localised isolate, not clearly pathogenic | HIV | No | Sigler et al. [5] | AY744467 |
N hominis | Right thigh mass, lung lesion | HIV | Itraconazole | Sigler et al. [5] | KF477215 |
N guarroi/hominis | Inguinal node with disseminated adenopathy initially, after endocarditis, lungs, spleen and kidneys | Immunocompetent | Itraconazole, 2 years | Stchigel et al. [1], reclassified as N hominis in Sigler et al. [5] | HF547876.1 |
N obscura | Right ankle abcess, osteomyelitis | Immunocompetent | Amphotericin B, 4 months | Stillwell et al. [6] | KF477217 |
N obscura | Lung infiltration, brain abcess | HIV | Voriconazole | Steininger et al. [7] | HF547869 |
N obscura | Thoracic collection, lymphadenopathy and skin rash | Renal transplant | Posaconazole, 10 months | Baggott et al. [8] | Non available |
N obscura | Brain abcess | Leukemia | No | Nourrisson et al. [9] | KY771168.1 |
Nannizziopsis sp | Brain abcess | HIV | Amphotericin B 1 month, then voriconazole | Nourrisson et al. [9] | KY771169.1 |
Nannizziopsis vriesii/obscura | Brain abcess | NA | NA | Stchigel et al. [1], reclassified in Sigler et al. [5] as N. obscura | HF547869 |
Nannizziopsis obscura | Liver abcess | HIV | Amphotericin B liposomal | Garcia-Hermoso et al. [2] | MN982937 |
Nannizziopsis obscura | Fungemia, cutaneuous ulcers | Heart transplant | No | Garcia-Hermoso et al. [2] | MN982938 |
Nannizziopsis obscura | Disseminated subcutaneous abcess (legs, back), pulmonary nodules | Diabetes, renal transplant | Posaconazole, 8 months | Garcia-Hermoso et al. [2] | MN982939 |
Nannizziopsis obscura | Suppurated lesions (right ankle) and lung micronodules | Renal transplant | Posaconazole, 2 years | Garcia-Hermoso et al. [2] | MN982940 |
Nannizziopsis obscura | Skin hyperchromic nodules, pulmonary nodules and bronchial ulcerations | Mantle cell lymphoma | Terbinafine, when identifiation voriconazole and liposomal amphotericin B | Garcia-Hermoso et al. [2] | MN982941 |
Nannizziopsis obscura | Mediastinic abcess | Inmunocompetent | Posaconazole, when identification voriconazole | Garcia-Hermoso et al. [2] | MN982942 |
Nannizziopsis obscura | Brain abcess | Renal transplant | Liposomal amphotericin B and fluconazole, then liposomal amphotericin B and voriconazole | Garcia-Hermoso et al. [2] | MN982943 |
Nannizziopsis obscura | Subcutaneous abcess, pulmonary nodules | Renal transplant | Itraconazole, 4 months (ongoing) | Garcia-Hermoso et al. [2] | MN982944 |
Nannizziopsis obscura | Subcutaneous abcess | Renal transplant | Voriconazole, 3 months (ongoing) | Garcia-Hermoso et al. [2] | MT345076 |
Nannizziopsis spp. (not identified) | Disseminated osteomyelitis, pneumonia, brain abcesses | STAT1 gain of fuction mutation | Amphotericin B and voriconazole, then voriconazole with intention to maintain as prophylaxis | Most et al. [10] | MT104574 |