Genetic diversity of transmission-blocking vaccine candidate antigens Pvs25 and Pvs28 in Plasmodium vivax isolates from China

Table 3 Nucleotide diversity and tests of neutrality of the pvs25 gene in P. vivax isolates from six sites in China, 2009–2020

Sites	No. of isolates	S	H	Hd ± SD	K	π ± SD	Tajima’s D (P value)	dN
Dandong	7	1	2	0.571 ± 0.119	0.571	0.00097 ± 0.00020	1.34164 (P > 0.10)	0.57143
Suining	10	1	2	0.467 ± 0.132	0.467	0.00079 ± 0.00022	0.81980 (P > 0.10)	0.46667
Hainan	24	2	3	0.507 ± 0.093	0.623	0.00106 ± 0.00023	0.35972 (P > 0.10)	0.62319
Nyingchi	24	3	4	0.699 ± 0.048	1.054	0.00179 ± 0.00015	0.78580 (P > 0.10)	1.05434
Tengchong	205	4	7	0.489 ± 0.039	0.724	0.00123 ± 0.00011	0.12056 (P > 0.10)	0.72434
Yingjiang	54	3	4	0.473 ± 0.071	0.521	0.00089 ± 0.00016	− 0.42264 (P > 0.10)	0.52131
Total	324	5	8	0.621 ± 0.021	0.859	0.00146 ± 0.00007	0.16474 (P > 0.10)	0.00186

S number of polymorphic sites, H number of haplotypes, Hd haplotype diversity, K average number of nucleotide differences, π nucleotide diversity, dN number of non-synonymous substitutions

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