Table 2 Number of antibiotic-days by day 30 for varying adherence to antibiotic withholding guidance for the lowest procalcitonin level (≤ 0.1 mcg/L) in-hospital (inpatient and emergency department), low procalcitonin level (≤ 0.25 mcg/L) in the emergency department only, and low procalcitonin level (≤ 0.25 mcg/L) post-discharge
Adherence | Procalcitonin ≤ 0.1 mcg/L ED and inpatient | Procalcitonin ≤ 0.25 mcg/L ED only | Procalcitonin ≤ 0.25 mcg/L Post-discharge | ||||||
|---|---|---|---|---|---|---|---|---|---|
Mean Days | Difference from usual care (95% CI) | p-value | Mean Days | Difference from usual care (95% CI) | p-value | Mean Days | Difference from usual care (95% CI) | p-value | |
100%a | 3.6 | − 0.7 (− 1.6, − 1.3) | 0.011 | 4.0 | − 0.3 (− 1.2, − 0.9) | 0.273 | 2.6 | − 1.7 (− 2.5, − 2.2) | < 0.001 |
95% | 3.6 | − 0.6 (− 0.7, − 0.6) | 0.026 | 4.0 | − 0.3 (− 0.3, − 0.3) | 0.328 | 2.8 | − 1.5 (− 1.5, − 1.4) | < 0.001 |
90% | 3.7 | − 0.6 (− 0.6, − 0.5) | 0.052 | 4.0 | − 0.3 (− 0.3, − 0.2) | 0.388 | 3.1 | − 1.2 (− 1.3, − 1.1) | < 0.001 |
85% | 3.8 | − 0.5 (− 0.5, − 0.4) | 0.100 | 4.1 | − 0.2 (− 0.2, − 0.2) | 0.454 | 3.3 | − 1 (− 1.1, − 0.9) | < 0.001 |
80% | 3.9 | − 0.4 (− 0.4, − 0.4) | 0.173 | 4.1 | − 0.2 (− 0.2, − 0.2) | 0.526 | 3.5 | − 0.8 (− 0.9, − 0.7) | 0.006 |
75% | 4.0 | − 0.3 (− 0.4, − 0.3) | 0.282 | 4.1 | − 0.2 (− 0.2, − 0.1) | 0.605 | 3.7 | − 0.6 (− 0.7, − 0.5) | 0.052 |
70% | 4.1 | − 0.2 (− 0.3, − 0.2) | 0.430 | 4.2 | − 0.1 (− 0.1, − 0.1) | 0.688 | N/A | N/A | N/A |
65% | 4.1 | − 0.2 (− 0.2, − 0.1) | 0.616 | 4.2 | − 0.1 (− 0.1, − 0.1) | 0.774 | N/A | N/A | N/A |