Evaluation of Mycobacterium tuberculosis specific antigen-stimulated CD27−CD38+IFN-γ+CD4+ T cells for discrimination of active tuberculosis

Table 2 Diagnostic performance of different phenotypic markers

	Cutoff	Se	Sp	PPV	NPV	FPR	FNR	⁺LR	⁻LR	Accuracy	Youden
CD4⁺IFNγ⁺CD27⁻CD38⁺/CD4⁺	1.34 × 10^–4	0.869	0.849	0.907	0.792	0.151	0.130	5.753	0.154	0.862	0.718
CD4⁺IFNγ⁺CD27⁻/CD4⁺	2.11 × 10^–4	0.781	0.849	0.898	0.694	0.151	0.219	5.167	0.258	0.806	0.630
CD4⁺IFNγ⁺CD38⁺/CD4⁺	2.56 × 10^–4	0.776	0.791	0.864	0.675	0.209	0.224	3.721	0.283	0.782	0.568
CD4⁺IFNγ⁺CD27⁻CD38⁺/CD4⁺IFNγ⁺	1.91 × 10^–1	0.793	0.705	0.821	0.667	0.295	0.207	2.689	0.293	0.761	0.498
CD4⁺IFNγ⁺CD27⁻/CD4⁺IFNγ⁺	3.21 × 10^–1	0.624	0.777	0.827	0.548	0.223	0.376	2.800	0.483	0.681	0.401
CD4⁺IFNγ⁺CD38⁺/CD4⁺IFNγ⁺	1.80 × 10^–1	0.899	0.417	0.724	0.707	0.583	0.101	1.542	0.243	0.721	0.316

Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, FPR false positive rate, FNR false-negative rate, ⁺LR positive likelihood ratio, ⁻LR negative likelihood ratio

ISSN: 1471-2334