Table 5 Univariate and multivariate analysis of potential prognostic factors
Characteristic/Variable | N (%) | 5-year OS(%) | Univariate Analysis | Multivariate Analysis | |
|---|---|---|---|---|---|
P value | P value | HR (95% CI) | |||
Age (years) | 0.846 | – | – | ||
≤ 48 | 795 (55.8) | 90.9 | |||
> 48 | 630 (44.2) | 91.3 | |||
FIGO stage | 0.013 | 0.214 | – | ||
IA1–IB2 | 903 (63.4) | 92.5 | |||
IIA1–IIA2 | 522 (36.6) | 88.7 | |||
SCC-Ag (ng/ml) | 0.000 | 0.112 | - | ||
< 1.5 | 608 (42.7) | 94.7 | |||
≥ 1.5 | 817 (57.3) | 88.4 | |||
Histological grade | 0.039 | 0.576 | - | ||
G1 | 199 (14.0) | 95.0 | |||
G2–G3 | 1226 (86.0) | 90.5 | |||
Deep stromal invasion | 0.000 | 0.007 | 1.89 (1.19–2.99) | ||
Superficial (< 1/2) | 586 (41.1) | 95.6 | |||
Deep (≥ 1/2) | 839 (58.9) | 88.0 | |||
LVSI | 0.000 | 0.023 | 1.63 (1.07–2.48) | ||
Negative | 681 (47.8) | 94.9 | |||
Positive | 744 (52.2) | 87.6 | |||
Para-aortic/Pelvic LN | 0.000 | 0.000 | 2.56 (1.74–3.75) | ||
Negative | 1174 (82.4) | 93.7 | |||
Positive | 251 (17.6) | 78.9 | |||
Routes of surgery | |||||
Open | 1315 (92.3) | 90.9 | 0.344 | – | – |
Laparoscopic | 110 (7.7) | 93.6 | |||
Post-operative therapy | 0.001 | 0.684 | – | ||
None | 523 (36.7) | 94.1 | |||
Yes | 902 (63.3) | 89.1 | |||
HR-HPV status | 0.243 | – | – | ||
Negative | 247 (17.4) | 89.1 | |||
Positive | 1178 (82.6) | 91.5 | |||
HR-HPV pattern | 0.474 | – | – | ||
Single | 998 (70.0) | 91.4 | |||
Multiple | 180 (12.6) | 92.2 | |||
HPV16 status | 0.057 | – | – | ||
Negative | 429 (30.0) | 89.1 | |||
Positive | 929 (70.0) | 92.1 | |||
HPV58 status | 0.505 | – | – | ||
Negative | 1301 (91.3) | 91.2 | |||
Positive | 124 (8.7) | 89.5 | |||
HPV18 status | |||||
Negative | 1316 (92.7) | 91.3 | 0.225 | – | – |
Positive | 109 (7.7) | 88.1 | |||
HPV52 status | |||||
Negative | 1361 (95.5) | 91.0 | 0.768 | – | – |
Positive | 64 (4.5) | 92.2 | |||
Total cases | 1425 | 91.1 | |||