Table 1 Simulated regimens designed according to 2016 treatment shortening target regimen profile [18]
From: A comparison of clinical development pathways to advance tuberculosis regimen development
Arm | Regimen | Duration (Weeks) | Assumed TCC hazard ratio | Assumed TTR hazard ratio | Median cure rate (%) |
|---|---|---|---|---|---|
0 | Control (HRZE) | 24 | Reference | Reference | 92.0 |
1 | Desirable (meets targets) | 8 | 3.4 | 0.6 | 90.0 |
2 | 12 | 92.5 | |||
3 | 16 | 93.5 | |||
4 | Minimal (minimum targets) | 8 | 1.9 | 0.7 | 86.5 |
5 | 12 | 87.5 | |||
6 | 16 | 90.5 | |||
7 | Suboptimal (below minimum targets) | 8 | 1.2 | 0.85 | 81.0 |
8 | 12 | 84.0 | |||
9 | 16 | 86.5 |