Fig. 5

Study duration and total recruitment comparison of BAR and MAMS. A Phase IIc and B Seamless Phase II/III comparisons. BAR and MAMS designs have comparable performance in graduating the best regimens and stopping the suboptimal regimens (demonstrated previously) while BAR consistently outperforms MAMS in study duration and total recruitment. Although both MAMS and BAR provide enormous time and patient savings compared to conventional clinical trials, the median Phase IIc BAR enrolls 80 fewer patients and saves 8 weeks of time compared to the Phase IIc MAMS and the median Seamless BAR enrolls 420 fewer patients and saves 42 weeks of time compared to the Seamless MAMS