Table 3 Multivariate logistic models for severe COVID-19 outcomes

Male sex

1.56 (1.54–1.57)

1.20 (1.18–1.22)

1.32 (1.30–1.34)

Age group

 20–

Ref.

Ref.

Ref.

 20–39

0.55 (0.54–0.57)

1.41 (1.30–1.54)

2.27 (2.07–2.48)

 40–59

1.86 (1.82–1.90)

2.18 (2.01–2.36)

5.12 (4.69–5.59)

 60+

12.56 (12.26–12.86)

2.57 (2.37–2.79)

13.80 (12.64–15.06)

Epidemic wave

 1st wave

Ref.

Ref.

Ref.

 2nd wave

0.54 (0.53–0.54)

0.74 (0.72–0.75)

1.43 (1.40–1.45)

 3rd wave

0.25 (0.25–0.26)

0.76 (0.74–0.78)

1.27 (1.24–1.30)

 4th wave

0.09 (0.09–0.09)

0.37 (0.36–0.39)

0.94 (0.91–0.97)

 5th wave

0.04 (0.04–0.04)

0.18 (0.16–0.19)

0.40 (0.38–0.42)

Previous medical conditions

 None

Ref.

Ref.

Ref.

 One

2.15 (2.12–2.17)

1.16 (1.13–1.18)

1.29 (1.27–1.32)

 Two or more

3.79 (3.74–3.83)

1.15 (1.13–1.18)

1.52 (1.49–1.55)

COVID-19 vaccination

 Unvaccinated/incomplete

Ref.

Ref.

Ref.

 Complete/booster

0.41 (0.40–0.41)

0.96 (0.92–0.99)

0.75 (0.73–0.78)

Intubation

–

–

14.37 (14.02–14.73)

ICU care

–

–

0.48 (0.46–0.51)