Metagenomic analysis reveals differences in the co-occurrence and abundance of viral species in SARS-CoV-2 patients with different severity of disease

Table 3 Virus species differentially abundant in patients with diverse severity of infection

Viral species	All samples	Number of positive samples			Comparing dec/amb		Comparing hosp/amb		Comparing dec/hosp
	All samples	Deceased	Hospitalized	Ambulatory	Comparing dec/amb		Comparing hosp/amb		Comparing dec/hosp
	120	57	26	37	lfch^a	FDR^b	lfch	FDR	lfch	FDR
TTMDV 8	10	6	3	1	4.201^c	0.025	4.279	0.021	0.078	0.97
TTMV 19	9	6	2	1	16.118	3.04E-07	9.947	0.0004	− 6.171	0.093
TTMV 26	8	4	3	1	4.815	0.003	4.298	0.021	− 0.517	0.944
HHV-6	19	12	7	0	9.986	1.98E-06	11.361	1.24E-06	1.374	0.595
HuACyV10	8	7	1	0	12.793	1.07E-06	13.305	1.81E-06	0.511	0.944
RVA	14	11	1	2	4.516	0.013	− 1.925	0.395	− 6.442	0.016
MV	8	8	0	0	14.037	4.90E-07	0	1	− 14.037	0.0005
HPV-6	7	7	0	0	14.851	4.90E-07	0	1	− 14.851	0.00003

^alog fold change
^bFDR represents the p-value adjusted by FDR using Benjamini–Hochberg correction
^cSignificant results are in bold

ISSN: 1471-2334