Table 6 Characteristics of patients with E. coli bacteraemia tested for trimethoprim resistance who did/did not die

N

6401

4157 (64.9%)

2244 (35.1%)

Ever received trimethoprim

No

Yes

2071 (32.4%)

4330 (67.6%)

1261 (60.9%)

2896 (66.9%)

810 (39.1%)

1434 (33.1%)

p < 0.001

Gender

Female

Male

3807 (59.5%)

2594 (40.5%)

2603 (68.4%)

1554 (59.9%)

1204 (31.6%)

1040 (40.1%)

p < 0.001

Age category at first trimethoprim use

16-34

35-49

50-64

 > 65

233 (3.6%)

416 (6.5%)

1052 (16.4%)

4700 (73.4%)

217 (93.1%)

332 (79.8%)

765 (72.7%)

2843 (60.5%)

16 (6.9%)

84 (20.2%)

287 (27.3%)

1857 (39.5%)

p < 0.001

Age at first trimethoprim use

Mean (SD)

70.9 (15.6)

71.0 (16.1)

72.8 (14.2)]

p = 0.332

SIMD quintile (Q1 = Most Deprived, Q5 = Least Deprived)

Q1

Q2

Q3

Q4

Q5

1625 (25.5%)

1483 (23.3%)

1215 (19.1%)

1052 (16.5%)

989 (15.5%)

1084 (66.7%)

963 (64.9%)

796 (65.5%)

678 (64.4%)

605 (61.2%)

541 (33.3%)

520 (35.1%)

419 (34.5%)

374 (35.6%)

384 (38.8%)

p = 0.071

Long-term users of trimethoprim

No

Yes

6136 (95.9%)

265 (4.1%)

3968 (64.7%)

189 (71.3%)

2168 (35.3%)

76 (28.7%)

p = 0.030

At least one treatment failure of trimethoprim (different antimicrobial within 60 days); includes prescriptions dispensed before 01/11/2012

No

Yes

5698 (89.0%)

703 (11.0%)

3678 (64.5%)

479 (68.1%)

2020 (35.5%)

224 (31.9%)

p = 0.065

Resistant

No

Yes

3523 (55.0%)

2878 (45.0%)

2412 (68.5%)

1745 (60.6%)

1111 (31.5%)

1133 (39.4%)

p < 0.001