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Table 4 Treatment measures, complications, and clinical outcomes

From: Association between active cytomegalovirus infection and lung fibroproliferation in adult patients with acute respiratory distress syndrome: a retrospective study

 

Total

Active CMV infection

P

N = 87

Yes (n = 14, 16.1%)

No (n = 73, 83.9%)

Treatment measures, n (%)

 Before ICU admission

  Glucocorticoids

32 (36.8)

6 (42.9)

26 (35.6)

0.607

  Immunosuppressive drugs^

12 (13.8)

2 (14.3)

10 (13.7)

> 0.999

  Gamma globulin infusions

10 (11.5)

0 (0)

10 (13.7)

0.310

  Blood transfusiona

13 (15.0)

5 (35.7)

8 (11.0)

0.049

 After ICU admission

  Glucocorticoids

25 (28.7)

3 (21.4)

22 (30.1)

0.736

  Immunosuppressive drugs^

4 (4.6)

1 (7.1)

3 (4.1)

0.511

  Gamma globulin infusions

19 (21.8)

4 (28.6)

15 (20.6)

0.755

  Blood transfusion

38 (43.7)

8 (57.1)

30 (41.1)

0.267

 Antiviral therapy#a

14 (16.1)

14 (100)

0 (0)

< 0.001

  CRRT

34 (39.1)

7 (50.0)

27 (37.0)

0.361

  ECMO

13 (14.9)

2 (14.3)

11 (15.1)

> 0.999

Complications, n (%)

 Septic shocka

56 (64.4)

13 (92.9)

43 (58.9)

0.034

  AKI

44 (50.6)

10 (71.4)

34 (46.6)

0.088

  DIC

24 (27.6)

6 (42.9)

18 (24.7)

0.285

  AHF

16 (18.4)

5 (35.7)

11 (15.1)

0.147

  AECOPD

13 (14.9)

2 (14.3)

11 (15.1)

> 0.999

 Clinical outcomes

  28-day VFD (d)

0 (0–13)

0 (0–0)

0 (0–14)

0.134

  Length of IMV

27 (13–55)

40 (26–82)

24 (13–51)

0.072

 Duration of ICU staya (d)

30 (15–57)

51 (26–104)

29 (15–57)

0.035

  Duration of hospital stay (d)

39 (26–85)

56 (32–127)

39 (26–80)

0.330

  In-hospital mortality, n (%)

8 (9.2)

2 (14.3)

6 (8.2)

0.830

  1. CMV: Cytomegalovirus; CRRT: continuous renal replacement therapy; ECMO: extracorporeal membrane oxygenation; AHF: acute heart failure; AKI: acute kidney failure; DIC: disseminated intravascular coagulation; VFD: ventilator-free days; IMV: invasive mechanical ventilation
  2. aP < 0.05; Categorical variables were expressed as n (%), Continuous variables were expressed as Median (IQRs); #, included ganciclovir, valganciclovir, or sodium phosphate; ^, included cyclophosphamide, methotrexate, and mycophenolate mofetil. Bold font indicates the difference was statistically significant