Table 2 Quality parameters of anti-HCV detection in dried blood spot samples using commercial EIA according to the population under analysis and their serological profile
Profile | TP | FN | TN | FP | Sensitivity% (95% CI) | Specificity% (95% CI) | PPV% (95% CI) | NPV% (95% CI) | Accuracy (95% CI) | wK (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
GI) General population (n = 1042) | 6 | 1 | 1027 | 8 | 85.7 (42.1–99.6) | 99.2 (98.4–99.6) | 42.8 (26.0–61.4) | 99.9 (99.4- 99.8) | 99.1 (98.4–99.6) | 0.6 (0.3- 0.8) |
Tocantins/Tocantinopolis (n = 582) | 3 | 0 | 575 | 4 | 100.0 (29.2–100.0) | 99.3 (98.2–99.8) | 42.8 (22.0–66.6) | 100.0 (NA) | 99.3 (98.2–99.8) | 0.6 (0.2–0.9) |
Rio de Janeiro/Nova Iguaçu (n = 131) | 2 | 0 | 129 | 0 | 100.0 (15.8–100.0) | 100.0 (97.2–100.0) | 100.0 (NA) | 100.0 (NA) | 100.0 (97.2–100.0) | 1.000 (NA) |
Mato Grosso do Sul/Pantanal (n = 329) | 1 | 1 | 323 | 4 | 50.0 (1.3–98.7) | 98.8 (96.9–99.6) | 20.0 (4.4–57.6) | 99.7 (98.7–99.9) | 98.5 (96.5–99.5) | 0.3 (0.1–0.7) |
GII) Beauty Professionals (n = 288) | 3 | 0 | 284 | 1 | 100.0 (29.2–100.0) | 99.6 (98.0–99.9) | 75.0 (29.8–95.5) | 100.0 (NA) | 99.6 (98.1–99.9) | 0.8 (0.6–1) |
GIII) Non injecting drug users (n = 201) | 1 | 0 | 197 | 3 | 100.0 (2.5–100.0) | 98.5 (95.7–99.7) | 25.0 (9.8–50.6) | 100.0 (NA) | 98.5 (95.7–99.7) | 0.4 (0.1–0.9) |
GIV) Ambulatory settings (n = 275) | 240 | 4 | 31 | 0 | 98.3 (95.8–99.5) | 100.0 (88.8–100.0) | 100.0 (NA) | 88.6 (74.6–95.3) | 98.5 (96.3–99.6) | 0.9 (0.9–1.0) |
All Individuals (1806) | 250 | 5 | 1539 | 12 | 98.0 (95.5–99.4) | 99.2 (98.7–99.6) | 95.4 (92.2–97.3) | 99.7 (99.2–99.8) | 99.0 (98.5–99.4) | 0.9 (0.9–1.0) |