Clinical and laboratory features in patients with positive syphilis serology presenting with acute ischemic stroke or transient ischemic attack: a prospective cohort study

Table 4 Outcome comparison of patients without and with latent syphilis and neurosyphilis

	Controls	Latent syphilis	Neurosyphilis	p-value^#	P1	P2	P3
Modified Rankin Scale*
Initial (points), median (P25, P75)	4 (3, 5)	5 (4, 5)	5 (4, 5)	0.022	0.095	0.022	0.12
3 months (points), median (P25, P75)	2 (1, 4)	3 (2, 5)	4 (4, 5)
p-value (difference between initial and 3-month scores)	< 0.001	0.001	0.236
Change from initial (3-month score–initial score), median (P25, P75)	− 1 (− 2, 0)	− 1 (− 2, 0.5)	0 (− 1, 0)	0.077	0.124	0.076	0.448
Barthel Index**
Initial (points), median (P25, P75)	50 (30, 75)	50 (20, 65)	55 (10, 60)	0.204	0.14	0.27	0.69
3 months (points), median (P25, P75)	100 (50, 100)	90 (5, 100)	40 (0, 90)	0.001	0.030	0.002	0.095
p-value (difference between initial and 3-month scores)	< 0.001	0.001	0.838
Change from initial (3-month score–initial score), median (P25, P75)	25 (0, 44)	25 (− 5, 40)	− 10 (− 20, 25)	0.028	0.274	0.012	0.076

P1 controls compared with latent syphilis, P2 controls compared with neurosyphilis, P3 latent syphilis compared with neurosyphilis, P25 25th percentile, P75 75th percentile
^#The Kruskal–Wallis H test was used to compare median of the outcomes between the three groups
*Scores on the modified Rankin scale (mRS) range from 0 (no symptoms) to 6 (death)
**The Barthel Index (BI) scores range from 0 (totally dependent) to 100 (normal activities of daily living)

ISSN: 1471-2334