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Table 1 The pathogens identified in patients with hand-foot-mouth disease in Yunnan, China, 2019

From: Co-infection and enterovirus B: post EV-A71 mass vaccination scenario in China

Virus

Total (n = 459)

P

No

%

Enterovirus infection

348

75.82

 

 Average age

2.80 ± 1.90

 

 Single enterovirus infection

191

41.61

< 0.01

Enterovirus A

119

25.9

 

 CVA6

52

11.33

< 0.01

 CVA4

24

5.23

< 0.01

 CVA16

16

3.49

< 0.01

 CVA10

9

1.96

0.786

 CVA5

9

1.96

–

 EV71

2

0.44

< 0.01

 Other Enterovirus A

9

1.96

0.786

Enterovirus B

72

15.7

 

 CVB1

41

8.93

< 0.01

 CVA9

21

4.58

< 0.01

 Other Enterovirus B

10

2.18

0.031

Co-infection

157

34.20

< 0.01

 EV71 + other EVs (except CVA6 + CVA16)

9

1.96

–

 CVA6 + other EVs (except EV71 + CVA16)

70

15.25

< 0.01

 CVA6 + CVA16 + other EVs (except EV71)

7

1.53

0.661

 CVA16 + other EVs (except EV71 + CVA6)

46

10.02

< 0.01

 Other EVs

25

5.01

< 0.01

Non-enterovirus infection

111

24.18

 
  1. Other Enterovirus A: CVA8 (n = 3), CVA2 (n = 2) and CVA12 (n = 2) ; Other Enterovirus B: E18 (n = 4), CVB2 (n = 1), CVB3 (n = 1), CVB4 (n = 1), E1 (n = 1), E6 (n = 1) and E30 (n = 1); –: Using the values of CVA5 and EV71 + other EVs (except CVA6 + CVA16) as references