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Table 1 RSV test positivity in MarketScan Commercial Claims and Medicare Supplemental Databases and the National Respiratory and Enteric Virus Surveillance System (2011–2019), total and stratified by tests type

From: RSV testing practice and positivity by patient demographics in the United States: integrated analyses of MarketScan and NREVSS databases

Variables

Test positivity, %

 
 

MarketScan*

 

NREVSS

All tests

(N = 1,418,020, 13.4%)

Antibody

(N = 32,900, 18.5%)

Antigen

(N = 786,065, 21.2%)

Viral culture

(N = 66,696, 1.1%)

PCR

(N = 532,359, 3.1%)

All tests

(N = 7,079,301, 9.2%)

Antigen

(N = 1,983,441, 16.0%)

Viral culture

(N = 471,707, 2.8%)

PCR

(N = 4,624,152, 7.9%)

Calendar year

         

 2011

16.1

19.2

21.0

1.6

2.2

13.0

17.3

3.5

8.7

 2012

16.0

19.9

22.0

1.2

1.8

13.2

17.3

3.4

10.2

 2013

15.3

19.8

22.4

1.2

2.3

12.2

16.9

3.4

9.7

 2014

11.9

15.1

19.1

0.9

1.9

8.8

13.6

2.3

7.0

 2015

13.7

16.8

21.1

0.9

2.5

9.6

15.7

2.6

7.9

 2016

14.1

19.6

22.2

0.8

2.8

8.7

14.6

1.7

7.5

 2017

12.6

18.1

20.7

1.0

2.8

8.5

14.8

1.3

7.5

 2018

11.0

18.7

21.2

0.7

3.6

8.7

15.2

1.8

7.8

 2019

11.1

16.3

20.9

0.3

4.8

8.5

14.3

2.3

7.9

Calendar quarter

         

 1

17.1

22.4

24.1

1.6

4.0

13.8

20.8

4.5

11.3

 2

4.6

8.0

9.7

0.5

0.9

3.5

6.3

1.1

2.7

 3

3.0

6.1

7.9

0.2

0.6

2.0

5.7

0.3

1.0

 4

15.4

18.6

22.6

1.3

4.7

11.1

17.0

3.1

9.3

HHS region

         

 Region 1—Boston

11.0

18.9

23.0

0.7

2.7

7.8

8.8

1.3

7.4

 Region 2—New York

7.6

13.0

18.9

1.8

3.0

8.1

14.9

4.5

6.9

 Region 3—Philadelphia

12.1

16.1

21.4

0.9

3.5

9.8

15.5

3.6

7.8

 Region 4—Atlanta

14.7

17.9

20.3

0.6

2.7

10.1

13.7

1.2

7.5

 Region 5—Chicago

11.7

22.8

22.2

1.1

3.4

9.6

19.8

4.6

7.5

 Region 6—Dallas

16.1

17.6

21.1

1.2

3.7

12.5

19.5

3.2

9.6

 Region 7—Kansas City

15.4

21.0

22.1

1.3

3.9

11.2

19.5

1.1

8.0

 Region 8—Denver

13.5

22.1

25.0

0.8

3.3

10.5

17.6

1.2

9.4

 Region 9—San Francisco

10.9

22.1

21.1

1.0

2.0

9.0

16.0

1.0

7.4

 Region 10—Seattle

9.4

25.4

23.6

0.5

2.5

8.5

14.0

2.1

7.8

 Unknown

14.8

18.2

22.1

0.6

3.4

    

Age group

         

 0

22.9

22.6

24.6

10.2

13.2

    

 1

19.0

17.8

21.1

4.0

8.8

    

 2

17.1

17.2

20.1

3.6

6.8

    

 3

12.6

15.2

16.9

1.4

4.5

    

 4

8.3

11.5

13.1

1.0

2.9

    

 5–9

3.0

5.6

7.8

0.5

1.1

    

 10–14

0.7

3.9

3.4

0.1

0.3

    

 15–17

0.4

3.9

3.2

0.1

0.2

    

 18–30

0.7

5.9

4.7

0.1

0.4

    

 31–40

0.7

3.2

4.7

0.1

0.4

    

 41–50

0.6

1.6

2.1

0.2

0.6

    

 51–64

0.8

1.1

1.6

0.1

0.8

    

 >  = 65

1.3

1.4

1.0

0.2

1.6

    

Clinical setting

         

 Inpatient visit

4.7

12.3

10.6

0.8

3.1

    

 Emergency visit

11.6

15.7

17.2

3.1

6.0

    

 Outpatient visit

14.2

19.9

22.1

0.8

2.2

    

Indication for testing

         

 Severe complication

6.4

16.3

18.1

0.5

3.8

    

 LRTI

37.5

35.3

44.4

4.6

14.1

    

 Asthma exacerbation

3.5

2.6

4.8

1.2

2.6

    

 URTI

5.0

6.4

6.9

0.5

1.8

    

 Respiratory symptoms

6.7

13.3

13.2

0.8

1.8

    

 Others (e.g., flu/RSV infection)

9.1

17.4

20.6

0.4

1.5

    
  1. *In MarketScan RSV tests were identified using the “strict” definition, which required an RSV-specific test procedure code or an unspecific procedure code that was accompanied by a diagnosis indicative of respiratory illness (see Additional file 1: Table S1). Positivity was measured as the proportion of RSV tests accompanied by diagnoses codes on laboratory claims or adjacent medical encounters. Positivity for tests in NREVSS was directly extracted from recorded test results
  2. MarketScan: MarketScan Commercial Claims and Medicare Supplemental Databases; NREVSS: National Respiratory and Enteric Virus Surveillance System; RSV: respiratory syncytial virus; PCR: polymerase chain reaction; HHS region: the U.S. Department of Health and Human Services region LRTIs: lower respiratory tract infections; URTIs: upper respiratory tract infections