Table 3 Absolute sensitivity and specificity of hrHPV DNA PCR (hrHPV DNA), p16(INK4a) IHC (p16) and the combined testing (p16 + DNA) to identify a HPV-driven oropharyngeal cancer
Absolute | Sensitivity | Specificity |
|---|---|---|
hrHPV DNA | Â | Â |
 n/N | 28/28 | 62/67 |
 % | 100% | 92.5% |
 (95% CI) | (87.7–100) | (83.4–97.5) |
p16 | Â | Â |
 n/N | 27/28 | 62/67 |
 % | 96.4% | 92.5% |
 (95% CI) | (81.7–99.9) | (83.4–97.5) |
p16 + DNA |  |  |
 n/N | 27/28 | 65/67 |
 % | 96.4% | 97.0% |
 (95% CI) | (81.7–99.9) | (89.9–99.6) |