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Table 3 Absolute sensitivity and specificity of hrHPV DNA PCR (hrHPV DNA), p16(INK4a) IHC (p16) and the combined testing (p16 + DNA) to identify a HPV-driven oropharyngeal cancer

From: Accuracy of high-risk HPV DNA PCR, p16(INK4a) immunohistochemistry or the combination of both to diagnose HPV-driven oropharyngeal cancer

Absolute

Sensitivity

Specificity

hrHPV DNA

  

 n/N

28/28

62/67

 %

100%

92.5%

 (95% CI)

(87.7–100)

(83.4–97.5)

p16

  

 n/N

27/28

62/67

 %

96.4%

92.5%

 (95% CI)

(81.7–99.9)

(83.4–97.5)

p16 + DNA

  

 n/N

27/28

65/67

 %

96.4%

97.0%

 (95% CI)

(81.7–99.9)

(89.9–99.6)