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Table 1 Patient demographic and baseline characteristics

From: 2-deoxy-d-glucose as an adjunct to standard of care in the medical management of COVID-19: a proof-of-concept and dose-ranging randomised phase II clinical trial

  

2-DG 63 mg + SOC

N = 22

n (%)

SOC1

N = 22

n (%)

2-DG 90 mg

 + SOC

N = 22

n (%)

2-DG 126 mg

 + SOC

N = 21

n (%)

SOC2

N = 22

n (%)

Age (years)

Mean (SD)

44.2 (12.71)

44.4 (9.59)

46.3 (11.00)

42.7 (9.33)

46.6 (11.96)

Weight (kg)

Mean (SD)

61.3 (9.35)

67.9 (9.76)

69.4 (10.52)

74.2 (12.23)

70.6 (11.77)

Gender [n (%)]

Female

7 (31.8)

6 (27.3)

1 (4.5)

5 (23.8)

2 (9.1)

Male

15 (68.2)

16 (72.7)

21 (95.5)

16 (76.2)

20 (90.9)

Number of days since onset of first symptom of COVID-19

Mean (SD)

6.6 (2.26)

7.2 (2.58)

4.5 (1.41)

4.3 (1.46)

4.4 (1.40)

Clinical severity status as defined by MoH&FW [n (%)]

Group 1 (Mild)

0

0

0

0

0

Group 2 (Moderate)

21 (95.5%)a

21 (95.5%)a

22 (100.0%)

21 (100.0%)

21 (95.5%)a

Group 3 (Severe)

0

0

0

0

0

Oxygen saturation

(SpO2%)

N

22

21

22

21

21

Mean (SD)

93.1 (2.39)

93.0 (1.82)

92.7 (1.55)

92.5 (1.47)

93.0(2.07)

Median

92.0

93.0

93.0

93.0

93.0

Heart rate (beats per minute)

N

22

21

22

21

21

Mean (SD)

85.0 (11.32)

86.3 (15.17)

81.3 (10.39)

84.9 (11.57)

89.6 (8.48)

Median

80.0

84.0

80.0

88.0

89.0

Respiratory rate (per minute)

N

22

21

22

21

21

Mean (SD)

22.1 (3.04)

21.4 (3.20)

23.9 (2.41)

24.4 (2.09)

24.7 ± 2.61

Median

24.0

22.0

25.0

25.0

25.0

WHO clinical progression scale

N

22

22

22

21

22

Mean (SD)

5.1 (0.35)

5.0 (0.21)

4.3 (0.48)

4.3 (0.46)

4.3 (0.48)

Median

5.0

5.0

4.0

4.0

4.0

  1. 2-DG 2-deoxy-d-glucose, SOC standard of care, SOC1 SOC in Part A of the study, SOC2 SOC in Part B of the study
  2. N: Total number of patients in the specified treatment group
  3. n: Total number of patients in a given category
  4. Percentages are based on the total number of patients in the specified treatment group
  5. MoH&FW: Ministry of Health & Family Welfare, Government of India
  6. aSeverity assessment was missing for 1 patient each in these three groups