Table 2 Demographic characteristics and laboratory findings of pyogenic liver abscess patients with sepsis or prolonged hospital stays
| Â | Sepsis | Prolonged hospital stays | ||||
|---|---|---|---|---|---|---|
|  | Sepsis (n = 80) | Non-sepsis (n = 292) | p value |  > 21d (n = 61) |  ≤ 21d (n = 311) | p value |
Age (years) | 63.5 ± 13.6 | 61.4 ± 13.4 | 0.210 | 65.8 ± 13.8 | 61.0 ± 13.3 | 0.011 |
Gender (male), n (%) | 50(62.5) | 165(56.5) | 0.336 | 30(49.2) | 127(40.8) | 0.228 |
BMI | 24(22–26) | 23.5(22–26) | 0.115 | 23.5(21.3–25.5) | 24(22–26) | 0.717 |
Comorbidities | Â | Â | Â | Â | Â | Â |
 Hypertension | 31(38.8) | 104(35.6) | 0.606 | 30(49.2) | 105(33.8) | 0.022 |
 Diabetes mellitus | 39(48.8) | 116(39.7) | 0.147 | 33(54.1) | 122(39.2) | 0.031 |
 Fatty liver | 16(20.0) | 24(8.2) | 0.003 | 12(19.7) | 28(9.0) | 0.014 |
 Cholelithiasis | 16(20.0) | 76(26.0) | 0.268 | 16(26.2) | 76(24.4) | 0.767 |
 Viral hepatitis | 9(11.2) | 48(16.4) | 0.254 | 8(13.1) | 49(15.8) | 0.601 |
 Chronic renal insufficiency | 20(25.0) | 7(2.4) |  < 0.001 | 12(19.7) | 15(4.8) |  < 0.001 |
 Malignancy | 5(6.2) | 9(3.1) | 0.187 | 3(4.9) | 11(3.5) | 0.604 |
 Cardiovascular diseases | 16(20.0) | 54(18.5) | 0.760 | 18(29.5) | 52(16.7) | 0.019 |
 Hepatic dysfunction | 30(37.5) | 40(13.7) |  < 0.001 | 19(31.1) | 51(16.4) | 0.007 |
 Gastrointestinal surgery history | 8(10.0) | 38(13.0) | 0.468 | 6(9.8) | 40(12.9) | 0.512 |
 Microbiological etiology |  |  | 0.022 |  |  | 0.173 |
Klebsiella pneumoniae | 39(48.8) | 106(36.3) | Â | 30(49.2) | 115(37.0) | Â |
 Escherichia coli | 18(22.5) | 52(17.8) |  | 11(18.0) | 59(19.0) |  |
 Others | 23(28.8) | 134(45.9) |  | 20(32.8) | 137(44.1) |  |
Abscess size(cm) | Â | Â | 0.994 | Â | Â | 0.025 |
 < 5 | 21(26.2) | 75(25.7) |  | 11(18.0) | 85(27.3) |  |
 5–10 | 54(67.5) | 199(68.2) |  | 42(68.9) | 211(67.8) |  |
 > 10 | 5(6.2) | 18(6.2) |  | 8(13.1) | 15(4.8) |  |
Abscess number | Â | Â | 0.914 | Â | Â | 0.612 |
 Single lesion | 64(80.0) | 232(79.5) |  | 50(82.0) | 246(79.1) |  |
 Multiple lesions | 16(20.0) | 60(20.5) |  | 11(18.0) | 65(20.9) |  |
Treatment | Â | Â | 0.168 | Â | Â | 0.060 |
 Antibiotics alone | 14(17.5) | 78(26.7) |  | 8(13.1) | 84(27.0) |  |
 Antibiotics + Percutaneous drainage | 62(77.5) | 206(70,5) |  | 50(82.0) | 218(70.1) |  |
 Antibiotics + Surgical drainage | 4(5.0) | 8(2.7) |  | 3(4.9) | 9(2.9) |  |
Complications | Â | Â | Â | Â | Â | Â |
 Acute respiratory distress syndrome | 6(7.5) | 2(0.7) | 0.000 | 5(8.2) | 3(1.0) | 0.004 |
 Peritoneal effusion | 11(13.8) | 22(7.5) | 0.083 | 8(13.1) | 25(8.0) | 0.202 |
 Spontaneous rupture of abscess | 4(5.0) | 1(0.3) | 0.008 | 3(4.9) | 2(0.6) | 0.033 |
 Extrahepatic manifestations | 16(20.0) | 4(1.4) | 0.000 | 10(16.4) | 10(3.2) | 0.000 |
ICU admission | 22(27.5) | 7(2.4) | 0.000 | 14(23.0) | 15(4.8) | 0.000 |
Laboratory findings |  |  |  |  |  |  |
 WBC (109/L) | 12.5(10.6–16.8) | 11.2(8.8–15.2) | 0.013 | 12.5(10.5–16.6) | 11.3(8.9–15.2) | 0.047 |
 Hb (g/L) | 120.0(108.0–133.8) | 118.5(105.0–129.0) | 0.316 | 120(101.5–128) | 119(106–130.5) | 0.459 |
 PLT (109/L) | 98.0(66.0–167.5) | 221.5(151.5–332.8) |  < 0.001 | 135(79.5–225) | 210(136–318) |  < 0.001 |
 Neu (109/L) | 11.1(9.2–15.1) | 9.1(6.9–12.6) |  < 0.001 | 10.7(9.0–14.5) | 9.4(7.0–12.9) | 0.007 |
 Ly (109/L) | 0.6(0.5–1.0) | 1.2(0.7–1.6) |  < 0.001 | 0.7(0.5–1.3) | 1.1(0.7–1.5) | 0.003 |
 NLR | 19.2(10.4–26.5) | 8.3(5.1–14.7) |  < 0.001 | 15.3(8.8–21.5) | 9.3(5.2–15.9) |  < 0.001 |
 BUN (mmol/L) | 8.2(5.2–12.4) | 4.6(3.6–6.0) |  < 0.001 | 6.9(4.2–10.2) | 4.8(3.7–6.5) |  < 0.001 |
 Cr (μmol/L) | 78.0(63.5–110.3) | 63.0(53.0–78.0) |  < 0.001 | 76(51–100.5) | 66(54–78.5) | 0.050 |
 ALT (U/L) | 71.0(43.5–115.5) | 45.0(26.0–77.0) |  < 0.001 | 56(35.5–104.5) | 48(27–82.5) | 0.148 |
 ALP (U/L) | 152.5(104.0–234.0) | 166.0(117.8–229.8) | 0.219 | 174(105.5–222.5) | 162(116–233.5) | 0.779 |
 TBIL (μmol/L) | 19.7(13.0–37.4) | 14.0(9.4–21.1) |  < 0.001 | 16.7(10.6–29.1) | 14.3(9.8–23.9) | 0.145 |
 TBA (μmol/L) | 8.2(4.3–20.0) | 5.2(2.9–9.9) |  < 0.001 | 9.4(5–15.5) | 5.3(2.8–10.1) | 0.002 |
 ALB (g/L) | 28.5 ± 5.6 | 31.6 ± 5.6 |  < 0.001 | 28.8 ± 4.7 | 31.4 ± 5.8 |  < 0.001 |
 CRP (mg/L) | 188(140.9–266.1) | 114(50.1–173) |  < 0.001 | 176.7(141.2–239.9) | 120(50.1–183.0) |  < 0.001 |
 FIB (g/L) | 6.7(5.7–7.8) | 6.4(5.6–7.6) | 0.302 | 6.9(6.0–7.9) | 6.4(5.6–7.6) | 0.044 |
 CPR | 1.8(1.0–3.6) | 0.5(0.2–1.0) |  < 0.001 | 1.5(0.9–3.0) | 0.5(0.3–1.2) |  < 0.001 |
 NLPR | 16.8(8.6–33.2) | 3.6(1.6–9.7) |  < 0.001 | 13.4(5.2–26.6) | 4.6(1.8–12.0) |  < 0.001 |
 FPR | 6.01(3.8–11.4) | 2.8(1.9–4.2) |  < 0.001 | 5.1(2.8–10.1) | 3.0(2.0–4.8) |  < 0.001 |