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Table 2 Clearance of Neisseria gonorrhoeae and Chlamydia trachomatis at all infected sites at 8th day

From: Randomized controlled trial of the relative efficacy of high-dose intravenous ceftriaxone and oral cefixime combined with doxycycline for the treatment of Chlamydia trachomatis and Neisseria gonorrhoeae co-infection

Infected sites Doxycycline + ceftriaxone (n = 61) Doxycycline + cefixime (n = 64) ORs (95% CI) p value
n % (95% CI) n % (95% CI)
Subjects eradicated CT
 Genital 36 100.0 41 100.0   1
 Pharyngeal 12 100.0 4 57.1   0.036
 Rectal 4 100.0 6 100.0   1
  Genital + pharyngeal 6 75.0 4 66.7 1.46 (0.1–28.6) 1
 Rectal + pharyngeal 0   1 25.0   1
 All sites 58 95.1 (86.5–98.3) 56 87.5 (77.2–93.5) 2.7 (0.6–16.8) 0.21
Subjects eradicated NG
 Genital 36 100.0 41 100.0   1
 Pharyngeal 12 100.0 6 85.7   0.37
 Rectal 4 100.0 6 100.0   1
 Genital + pharyngeal 6 75 5 83.3 0.6 (0.1–15.5) 1
 Rectal + pharyngeal 1 100.0 3 75.0   1
 All sites 59 96.7 (88.8–99.1) 61 95.3 (87.1–98.4) 1.45 (0.16–17.89) 1
Subjects eradicated CT and NG
 Genital 36 100.0 41 100.0   1
 Pharyngeal 12 100.0 3 42.9   0.009
 Rectal 4 100.0 5 83.3   1
 Genital + pharyngeal 6 75.0 2 33.3 5.2 (0.4–108.1) 0.28
 Rectal + pharyngeal 0 0.0 1 25.0   1
 All sites 58 95.1 (86.5–98.3) 52 81.2 (70.0–88.9) 4.41 (1.11–25.7) 0.026
  1. CT Chlamydia trachomatis; NG Neisseria gonorrhoeae