Fig. 1

Trend of central line-associated bloodstream infection according to the interventions. The three interventions were performed during the study. The pre-intervention period began in January 2018 and ended in May 2019. Maximal barrier precautions were performed from 1 June 2019. Automated notification of CVC days was performed from 1 October 2019. 2% chlorhexidine bathing was performed from 1 June 2021. Blue line with closed circle indicates monthly CLABSI rates during each period. Yellow line with open circle indicates median monthly CLABSI rates (3.1 CLABSI rates in the pre-intervention period and 1.2 CLABSI rates in the post-intervention period). Red line indicates the predictive value of CLABSI in the pre-intervention period (slope coefficient − 0.01), and green line indicates the predictive value of CLABSI in the post-intervention period (slope coefficient − 0.11). P slope change showed decreasing trend in CLABSI after multimodal interventions, but it was not statistically significant (P slope change = 0.30). CLABSI Central line-associated bloodstream infection