Carriage prevalence of Neisseria meningitidis in China, 2005–2022: a systematic review and meta-analysis

Yue, Mengmeng; Xu, Juan; Yu, Jianxing; Shao, Zhujun

doi:10.1186/s12879-022-07586-x

BMC Infectious Diseases

Table 1 Characterization of included 115 studies

From: Carriage prevalence of Neisseria meningitidis in China, 2005–2022: a systematic review and meta-analysis

ID	Study	First author	Province	Publication time	Study time	Sampling method	Testing method	NO. of age groups	Cases	Sample size	Carriage prevalence
1	Yueyun Lan-2012 [22]	Yueyun Lan	Zhejiang	2012	1985–2010	UN	UN	UN	1762	7649	23.04%
2	Ruichun Ding-2013 [23]	Ruichun Ding	Hunan	2013	2011–2012	UN	Isolation and culture	7	1	442	0.23%
3	Xiumin Liang-2018 [24]	Xiumin Liang	Yunnan	2018	2014	Cluster sampling	Isolation and culture	4	16	240	6.67%
4	Hongfei Zhang-2010 [25]	Hongfei Zhang	Inner Mongolia	2010	2007	Stratified random sampling	Isolation and culture	UN	13	221	5.88%
5	Weijun Hu-2020 [26]	Weijun Hu	Shaanxi	2020	2016–2017	Cluster sampling	Isolation and culture, PCR	UN	110	1539	7.15%
6	Yueqi Wang-2017 [27]	Yueqi Wang	Shaanxi	2017	2016	Cluster sampling	Isolation and culture, PCR	6	64	998	6.42%
7	Tingting Yang-2019 [28]	Tingting Yang	Shanxi	2019	2016–2017	UN	Isolation and culture	6	25	649	3.9%
8	Honglian Lai-2011 [29]	Honglian Lai	Fujian	2011	2010	Stratified random sampling	Isolation and culture	UN	0	335	0%
9	Jialing Zhang-2019 [30]	Jialing Zhang	Jiangsu	2019	2014–2016	Random sampling	Isolation and culture	8	150	1265	11.86%
10	Xianping He-2013 [31]	Xianping He	Sichuan	2013	2010	UN	Isolation and culture	UN	2	273	0.73%
11	Zunyu Liu-2016 [32]	Zunyu Liu	Shandong	2016	2008–2015	Random sampling	Isolation and culture	7	24	2362	1.02%
12	Yingtong Wang-2015 [33]	Yingtong Wang	Hebei	2015	2006–2013	Stratified cluster sampling	Isolation and culture	7	293	28,447	1.03%
13	Zhenwu Liu-2017 [34]	Zhenwu Liu	Anhui	2017	2015	Stratified cluster sampling	Isolation and culture	6	23	1093	2.10%
14	Haiying Deng-2010 [35]	Haiying Deng	Hainan	2010	2006	Stratified random sampling	Isolation and culture	UN	9	744	1.21%
15	Min Cui-2013 [36]	Min Cui	Guangdong	2013	2009–2011	Stratified random sampling	Isolation and culture	UN	6	791	0.8%
16	Xinghua Wu-2010 [37]	Xinghua Wu	Guangxi	2010	2008	Stratified cluster sampling	Isolation and culture	UN	22	367	5.99%
17	Deshan Qiu-2016 [38]	Deshan Qiu	Shandong	2016	2013–2014	Stratified random sampling	Isolation and culture	7	8	996	0.80%
18	Weiping Jiang-2014 [39]	Weiping Jiang	Jiangsu	2014	2011–2012	UN	Isolation and culture	UN	17	703	2.42%
19	Hongna Chu-2016 [40]	Hongna Chu	Hebei	2016	2013–2014	Stratified random sampling	Isolation and culture	7	16	442	3.62%
20	Yihong Zhou-2012 [41]	Yihong Zhou	Jiangsu	2012	2011	UN	Isolation and culture	8	14	320	4.38%
21	Bin Jia-2016 [42]	Bin Jia	Beijing	2016	2009–2013	UN	Isolation and culture	9	34	1224	2.78%
22	Hengcai Niu-2018 [43]	Hengcai Niu	Beijing	2018	2016	Cluster stratified random sampling	Isolation and culture	9	11	252	4.37%
23	Fei He-2020 [44]	Fei He	Zhejiang	2020	2013–2017	Volunteer recruiting	Isolation and culture, PCR	7	329	2807	11.72%
24	Weihua Xue-2016 [45]	Weihua Xue	Hebei	2016	2015–2015	Stratified random sampling	Isolation and culture	7	11	255	4.31%
25	Qingxiu Zheng-2019 [46]	Qingxiu Zheng	Beijing	2019	2015–2017	Cluster sampling	Isolation and culture	9	14	783	1.79%
26	Lei Geng-2017 [47]	Lei Geng	Hebei	2017	2015–2016	Stratified random sampling	Isolation and culture	7	11	215	5.12%
27	Yihong Liao-2017 [48]	Yihong Liao	Fujian	2017	2014–2016	UN	Isolation and culture	UN	0	600	0%
28	Fangqin Xie-2016 [49]	Fangqin Xie	Fujian	2016	2011	UN	Isolation and culture	UN	0	263	0%
29	Yunfeng Hu-2011 [50]	Yunfeng Hu	Fujian	2011	2009	Stratified random sampling	Isolation and culture	UN	0	188	0%
30	Shiguo Liang-2011 [51]	Shiguo Liang	Heilongjiang	2011	2009	Random sampling	Isolation and culture	UN	11	210	5.24%
31	Yongfei Yan-2018 [52]	Yongfei Yan	Hebei	2018	2009–2015	Stratified random sampling	Isolation and culture	7	100	3528	2.83%
32	Xiaolei Tang-2010 [53]	Xiaolei Tang	Qinghai	2010	2007	UN	Isolation and culture	5	11	480	2.30%
33	Maolin Wang-2011 [54]	Maolin Wang	Shandong	2011	2007–2010	Simple random sampling	Isolation and culture	7	14	1470	0.95%
34	Zhijun Wang-2010 [55]	Zhijun Wang	Henan	2010	2004–2008	UN	Isolation and culture	5	32	855	3.74%
35	Yemin Qi-2014 [56]	Yemin Qi	Hebei	2014	2000–2013	UN	Isolation and culture	UN	232	4865	4.77%
36	Lin Luan-2014 [57]	Lin Luan	Jiangsu	2014	2005–2012	Cluster sampling	Isolation and culture, PCR	UN	26	4043	0.64%
37	Caixia Hao-2010 [58]	Caixia Hao	Sichuan	2010	2008–2009	UN	Isolation and culture	7	6	212	2.83%
38	Jingzhi Gao-2019 [59]	Jingzhi Gao	Hubei	2019	2008–2018	UN	UN	UN	93	2818	3.30%
39	Rongwei Lan-2014 [60]	Rongwei Lan	Guangxi	2014	2011	Cluster stratified random sampling	Isolation and culture	5	112	1311	8.54%
40	Yafei Wang-2013 [61]	Yafei Wang	Shandong	2013	2012	UN	UN	UN	5	430	1.16%
41	Qian Liu-2013 [62]	Qian Liu	Henan	2013	2010–2012	UN	Isolation and culture	UN	99	1653	5.99%
42	Xufang Ye-2017 [63]	Xufang Ye	Guizhou	2017	2006	Stratified random sampling	Isolation and culture	UN	3	726	0.41%
43	Ling Yuan-2012 [64]	Ling Yuan	Fujian	2012	2009	UN	Isolation and culture	UN	3	727	0.4%
44	Huanzhang Yuan-2012 [65]	Huanzhang Yuan	Guangdong	2012	2008–2010	UN	Isolation and culture	7	7	737	0.95%
45	Dan Xiao-2011 [66]	Dan Xiao	Liaoning	2011	2002–2009	UN	UN	UN	8	1990	0.4%
46	Fengyun Cheng-2012 [67]	Fengyun Cheng	Anhui	2012	2009	Stratified random sampling	Isolation and culture	UN	2	80	2.5%
47	Xiang Sun-2018 [68]	Xiang Sun	Jiangsu	2018	2014–2015	UN	Isolation and culture	UN	76	755	10.07%
48	Haitao Liu-2016 [69]	Haitao Liu	Beijing	2016	2013–2015	Stratified random sampling	Isolation and culture	UN	41	756	5.42%
49	Suxin Xu-2013 [70]	Suxin Xu	Hebei	2013	2012	Stratified random sampling	Isolation and culture	7	16	420	3.81%
50	Junrong Lu-2013 [71]	Junrong Lu	Hebei	2013	2012	Stratified random sampling	Isolation and culture	5	8	382	2.09%
51	Junhong Li-2010	Junhong Li	China	2010	2009	UN	UN	UN	92	9743	0.94%
52	Manshi Li-2010 [72]	Manshi Li	Shandong	2010	2008–2009	UN	Isolation and culture	7	13	1097	1.19%
53	Xuan Deng-2018 [73]	Xuan Deng	Zhejiang	2018	2006–2017	UN	UN	UN	4	2524	0.16%
54	Lijun Chen-2012 [74]	Lijun Chen	Guangdong	2012	2006–2008	UN	Isolation and culture	UN	1	705	0.14%
55	Xiaoping Yan-2010 [75]	Xiaoping Yan	Sichuan	2010	2006–2008	Random sampling	Isolation and culture	6	13	540	2.4%
56	Heng Yuan-2010 [76]	Heng Yuan	Sichuan	2010	2005–2008	UN	Isolation and culture	8	61	4369	1.40%
57	Jingjing Wu-2020 [77]	Jingjing Wu	Shandong	2020	2008–2018	UN	Isolation and culture	UN	34	3827	0.89%
58	Yan Wang-2016 [78]	Yan Wang	Liaoning	2016	2004–2013	UN	UN	UN	41	5197	0.79%
59	Shenxia Chen-2013 [79]	Shenxia Chen	Zhejiang	2013	2011–2013	Stratified random sampling	Isolation and culture	UN	5	152	3.29%
60	Quwen Li-2014 [80]	Quwen Li	Fujian	2014	2012	UN	Isolation and culture	UN	2	806	0.25%
61	Xiaofeng Yang-2007 [81]	Xiaofeng Yang	Hunan	2007	2006	Cluster sampling	Isolation and culture	7	10	367	2.72%
62	Xiaoqing Fu-2006 [82]	Xiaoqing Fu	Yunnan	2006	2005	UN	Isolation and culture	UN	14	979	1.43%
63	Taiping Yang-2007 [83]	Taiping Yang	Guangdong	2007	2006	Cluster sampling	Isolation and culture	5	9	352	2.56%
64	Xiaochun Li-2007 [84]	Xiaochun Li	Sichuan	2007	2005	UN	Isolation and culture	6	10	336	2.98%
65	Yushan Fan-2008 [85]	Yushan Fan	Hebei	2008	2001–2007	UN	Isolation and culture	UN	60	1792	3.35%
66	Fang Guo-2007 [86]	Fang Guo	Zhejiang	2007	2001–2006	UN	Isolation and culture	7	92	1779	5.17%
67	Sujie Shi-2006 [87]	Sujie Shi	Jiangsu	2006	2005	Random sampling	UN	9	8	470	1.70%
68	Shuxian Zhang-2009 [88]	Shuxian Zhang	Liaoning	2009	2006–2008	UN	Isolation and culture	UN	43	618	6.96%
69	Ye Chen-2007 [89]	Ye Chen	Liaoning	2007	2005	UN	UN	UN	13	229	5.68%
70	Qunwen Wen-2006 [90]	Qunwen Wen	Guangdong	2006	2005	Cluster sampling	Isolation and culture	7	10	717	1.39%
71	Changyan Ju-2008 [91]	Changyan Ju	Guangdong	2008	2005–2006	UN	Isolation and culture	7	55	1255	4.4%
72	Guohua Li-2006 [92]	Guohua Li	Shanxi	2006	2005	Random sampling	Isolation and culture	9	11	940	1.17%
73	Jianmin Zhang -2009 [93]	Jianmin Zhang	Zhejiang	2009	2003–2008	UN	Isolation and culture	3	87	1507	5.77%
74	Youju Jia-2008 [94]	Youju Jia	Qinghai	2008	2006–2007	UN	Isolation and culture	UN	11	450	2.44%
75	Yan Yang-2008 [95]	Yan Yang	Sichuan	2008	2007	UN	Isolation and culture, PCR	2	13	230	5.65%
76	Chunyuan Cao-2009 [96]	Chunyuan Cao	Fujian	2009	2006–2007	UN	Isolation and culture	UN	1	251	0.40%
77	Meng Yang-2007 [97]	Meng Yang	Jiangxi	2007	2005	UN	Isolation and culture	9	29	1441	2.01%
78	Xiaoqing Liu-2009 [98]	Xiaoqing Liu	Jiangxi	2009	2005–2007	UN	Isolation and culture	UN	55	3312	1.66%
79	Zhenglong Zhong-2008 [99]	Zhenglong Zhong	Jiangsu	2008	2005–2007	Random sampling	Isolation and culture	7	10	193	5.18%
80	Wen Lu-2008 [100]	Wen Lu	Heilongjiang	2008	2005	Random sampling	Isolation and culture	UN	3	230	1.30%
81	Jing Lv-2006 [101]	Jing Lv	Hubei	2006	2000–2005	UN	Isolation and culture	UN	213	4921	4.33%
82	Zhenyu Qian-2009 [102]	Zhenyu Qian	Hebei	2009	2007–2008	Stratified random sampling	Isolation and culture	7	163	7460	2.18%
83	Xiaoping Wang-2007 [103]	Xiaoping Wang	Anhui	2007	2005–2006	Simple random sampling	Isolation and culture	5	82	1868	4.39%
84	Xiujuan Yan-2006 [104]	Xiujuan Yan	Hainan	2006	2005	Random sampling	Isolation and culture	UN	14	617	2.27%
85	Tie Song-2007 [105]	Tie Song	Guangdong	2007	2005	UN	UN	UN	17	2413	0.70%
86	Lianfei Zhao-2007 [106]	Lianfei Zhao	Ningxia	2007	2007	Random sampling	UN	UN	0	210	0%
87	Jianying Yang-2005 [107]	Jianying Yang	Gansu	2005	2005	UN	Isolation and culture	9	2	742	0.27%
88	Ping Lin-2007 [108]	Ping Lin	Fujian	2007	2005	Random sampling	Isolation and culture	UN	1	190	0.530%
89	Huake Yang-2006 [109]	Huake Yang	Guangdong	2006	2005	UN	Isolation and culture	UN	0	226	0%
90	Shuhua Luo-2006 [110]	Shuhua Luo	Guangdong	2006	2005	UN	Isolation and culture	7	1	616	0.16%
91	Yan Teng-2009 [111]	Yan Teng	Jilin	2009	2008	Cluster sampling	Isolation and culture	7	0	210	0%
92	Yonggeng Zou-2009 [112]	Yonggeng Zou	Hunan	2009	2008	UN	Isolation and culture	7	1	240	0.42%
93	Huanying Gu-2009 [113]	Huanying Gu	Hebei	2009	2008	Stratified random sampling	Isolation and culture	UN	4	348	1.15%
94	Xinghua Wu-2009 [114]	Xinghua Wu	Guangxi	2009	2008	UN	Isolation and culture	UN	32	864	3.7%
95	Weijun Wang-2008 [115]	Weijun Wang	Chongqing	2008	2007	UN	Isolation and culture	UN	3	638	0.47%
96	Yinqi Sun-2008 [116]	Yinqi Sun	Hebei	2008	2007	UN	Isolation and culture	7	58	3618	1.60%
97	Rongna Huang-2009 [117]	Rongna Huang	Sichuan	2009	2007	Random sampling	Isolation and culture, PCR	5	11	999	1.1%
98	Qingmei Cong-2009 [118]	Qingmei Cong	Shandong	2009	2007–2008	UN	Isolation and culture	7	6	840	0.71%
99	Jianwen Yin-2007 [119]	Jianwen Yin	Yunnan	2007	2006	Cluster sampling	Isolation and culture	6	21	1249	1.68%
100	Lihua Ren-2008 [120]	Lihua Ren	Inner Mongolia	2008	2006	Stratified random sampling	Isolation and culture	7	8	210	3.81%
101	Yun Gong-2009 [121]	Yun Gong	Fujian	2009	2006	Stratified random sampling	Isolation and culture	UN	4	652	0.6%
102	Jun Wang-2007 [122]	Jun Wang	Ningxia	2007	2006	UN	Isolation and culture	UN	4	214	1.9%
103	Zuokui Xiao-2009 [123]	Zuokui Xiao	Shandong	2009	2007–2008	UN	Isolation and culture	UN	73	4836	1.52%
104	Xinchang Luo-2006 [124]	Xinchang Luo	Fujian	2006	2005	UN	Isolation and culture	UN	2	360	0.55%
105	Xin Li-2007 [125]	Xin Li	Inner Mongolia	2007	2005	UN	Isolation and culture	UN	27	711	3.80%
106	Hai Wang-2007 [126]	Hai Wang	Anhui	2007	2005	Random sampling	Isolation and culture	4	32	1047	3.06%
107	Lv You-2006 [127]	Lv You	Guizhou	2006	2005	UN	isolation and culture	9	17	904	1.88%
108	Meizhen Liu-2007 [128]	Meizhen Liu	Guangdong	2007	2005	UN	Isolation and culture	UN	7	1077	0.65%
109	Yan Zhang-2021 [129]	Yan Zhang	Shandong	2021	2009–2020	Recruitment	Isolation and culture, PCR	6	136	16,848	0.81%
110	Jinjun Luo-2021 [130]	Jinjun Luo	Hubei	2021	2013–2018	UN	Isolation and culture	7	370	4477	8.26%
111	Na Xie-2021 [131]	Na Xie	Xinjiang	2021	2012–2019	Cluster stratified random sampling	Isolation and culture, PCR	UN	351	2264	15.5%
112	Xiaohong Zhou-2021 [132]	Xiaohong Zhou	Jiangsu	2021	2018	UN	Isolation and culture	UN	7	411	1.70%
113	Man Jiang-2021 [133]	Man Jiang	Jiangsu	2021	2017–2018	Multistage stratified random sampling	Isolation and culture	8	15	772	1.94%
114	Chen Chen-2021 [134]	Chen Chen	Yunnan	2021	2020	Random Sampling	Isolation and culture, PCR	UN	17	1076	1.58%
115	Yunyi Zhang-2022 [135]	Yunyi Zhang	Zhejiang	2022	2015–2020	UN	Isolation and culture, PCR	UN	17	2827	0.64%

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