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Table 3 Molecular transmission cluster characteristics of Sichuan patients

From: Characterization of HIV-1 molecular epidemiology and transmitted drug-resistance in newly diagnosed HIV-infected patients in Sichuan, China

Variables

Total [n = 1297]a

In cluster(n = 205; 15.81%)

Out of cluster (n = 1092; 84.19%)

OR (95% CI)

P-values

AOR (95% CI)

P-values

Gender

 Maleb

936 [72.17]

148 (15.81)

788 (84.18)

1

   

 Female

361 [27.83]

57 (15.79)

304 (84.21)

0.857 (0.592–1.24)

0.413

  

Age (years)

 < 25b

71 [5.47]

2 (2.82)

69 (97.18)

1

   

 25~

183 [14.11]

14 (7.65)

169 (92.34)

1.434 (0.283–7.271)

0.664

  

 40~

197 [15.19]

25 (12.69)

172 (87.3)

1.406 (0.267–7.412)

0.688

  

 ≥ 50

846 [65.23]

164 (19.39)

682 (80.61)

1.875 (0.36–9.777)

0.456

  

Ethnicity

 Hanb

1212 [93.45]

200 (16.5)

1012 (83.49)

1

   

 Yi

66 [5.09]

5 (7.58)

61 (92.42)

0.669 (0.22–2.038)

0.48

  

 Others

19 [1.46]

0 (0)

19 (100)

-

0.998

  

Marital status

 Unmarriedb

228 [17.58]

22 (9.64)

206 (90.35)

1

   

 Married

727 [56.05]

133 (18.29)

594 (81.7)

1.149 (0.668–1.977)

0.616

  

 Divorced/widowed

337 [25.98]

49 (14.54)

288 (85.45)

0.75 (0.412–1.366)

0.347

  

 Unknownc

5 [0.39]

1 (20)

4 (80)

–

–

  

Occupation

 Farmersb

843 [65.00]

159 (18.86)

684 (81.13)

1

   

 Unemployed

184 [14.19]

22 (12.29)

157 (87.7)

0.851 (0.495–1.462)

0.559

  

 Retired

49 [3.78]

4 (8.16)

45 (91.83)

0.456 (0.151–1.375)

0.163

  

 Others/unknown

221 [17.04]

20 (8.84)

206 (91.15)

0.749 (0.417–1.345)

0.334

  

Route of transmission

 HETb

1190 [91.75]

202 (16.97)

988 (83.02)

1

0.429

  

 MSM

79 [6.09]

1 (1.26)

78 (98.73)

0.175 (0.022–1.387)

0.099

  

 IDUs

8 [0.62]

0 (0)

8 (100)

–

0.999

  

 Others/unknown

20 [1.54]

2 (10)

18 (90)

0.8 (0.139–4.594)

0.802

  

Drug resistanced

 

 DRb

72 [5.55]

4 (5.55)

68 (94.44)

1

 

1

 

 Non-DR

1225 [94.45]

201 (16.4)

1024 (83.59)

0.379 (0.132–1.092)

0.072

0.306 (0.106–0.881)

0.028*

Subtype

 

 CRF07_BCb

675 [52.04]

73 (10.81)

602 (89.18)

1

 

1

 

 CRF01_AE

343 [26.45]

78 (22.74)

265 (77.25)

2.161 (1.497–3.119)

< 0.001*

2.369 (1.659–3.382)

< 0.001*

 CRF08_BC

115 [8.87]

15 (13.04)

100 (86.95)

1.158 (0.624–2.15)

0.641

1.26 (0.685–2.314)

0.457

 CRF85_BC

67 [5.17]

13 (19.4)

54 (80.59)

1.546 (0.785–3.044)

0.208

1.686 (0.873–3.258)

0.120

 B

33 [2.54]

21 (63.63)

12 (36.36)

14.692 (6.607–32.668)

< 0.001*

13.723 (6.338–29.71)

< 0.001*

 Others

64 [4.93]

5 (7.81)

59 (92.18)

0.716 (0.272–1.885)

0.499

0.761 (0.293–1.977)

0.576

Education level

 

 Primary school or illiterateb

779 [60.06]

155 (19.89)

624 (80.1)

1

 

1

 

 Middle school

336 [25.91]

40 (11.9)

296 (88.09)

0.651 (0.427–0.993)

0.046*

0.584 (0.396–0.86)

0.006*

 High school or technical secondary school

99 [7.63]

9 (9.09)

90 (90.9)

0.707 (0.305–1.643)

0.421

0.457 (0.221–0.943)

0.034*

 Junior college or above

83 [6.40]

1 (1.20)

82 (98.80)

0.129 (0.015–1.101)

0.061

0.049 (0.007–0.362)

0.003*

  1. aNumbers in square brackets show the proportion of the cases as a percentage of the total 1297 subjects
  2. bThe reference value of this subgroup of variables
  3. cSet as missing value
  4. dDR indicates individuals with drug-resistant mutations, non-DR indicates individuals without drug-resistant mutations
  5. *P values < 0.05 were considered statistically significant
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BMC Infectious Diseases

ISSN: 1471-2334

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