Table 2 Summary of published cases of blood stream infection due to Pandoraea species
Author, country, year, reference | Age (years), sex | Strains | Symptoms | Underlying condition | Diagnostic method | Susceptibility MIC (μg/mL) | Other bacteria isolated | Treatment for Pandoraea | Outcome |
|---|---|---|---|---|---|---|---|---|---|
Stryjewski et al., 2003 (USA) [12] | 30, M | P. pnomenusa | Fever, hypotension | Pneumonia, pulmonary sarcoidosis, lung transplantation | PCR, gyrB gene sequencing | Zone diameter: IPM 33 mm; MEPM 6 mm | None | IPM, until dead | Died |
Johnson et al., 2004 (USA) [13] | 16, M | P. apista | Fever | CLABSI, cystic fibrosis | 16S rRNA sequencing | ND | Candida albicans | CVC removal, IPM and CTRX, 14 days | Survived |
Falces-Romero et al., 2016 (Spain) [14] | 10 months, F | P. pnomenusa | Fever, shaking chill | CLABSI, Leukemia | MALDI-TOF MS | Susceptible for MINO and IPM (Details unknown) | None | CVC removal, IPM, 10 days | Survived |
Xiao et al., 2019 (China) [15] | 43, M | P. sputorum | Elevated inflammatory markers | Hepatocellular carcinoma, liver transplantation | MALDI-TOF MS, 16S rRNA sequencing | AMK 32; AZT > 64; CFPM > 64; CAZ > 64; CPFX ≤ 0.5; CTRX ≤ 0.5; GM > 16; IPM ≤ 0.5; LVFX ≤ 1; MEPM 16; MINO ≤ 1; PIPC ≤ 16; PIPC/TAZ ≤ 8/4; ST ≤ 38/2 | None | IPM and CTRX/TAZ | Survived |
Gawalkar et al., 2020 (India) [16] | 42, M | P. pnomenusa | Fever, dyspnea | IE, prosthetic aortic valve replacement | ND | Susceptible for LVFX, MINO, ST (Details unknown) | none | LVFX | Died |
Bodendoerfer et al., 2021 (Switzerland) [17] | 37, M | P. pnomenusa | Fever | CLABSI, prosthetic valve endocarditis, IDU | Whole-genome sequencing | Strain 1: CAZ 24; CPFX 0.5; IPM 1.5; MEPM ≥ 32; MINO 0.38; PIPC 24; PIPC/TAZ 0.19; ST 0.64 | none | CVC removal, PIPC/TAZ, ST | Survived |
Strain 2: CAZ 16; CPFX 0.5; IPM 1.5; MEPM ≥ 32; PIPC 8; PIPC/TAZ 0.047; ST 0.64 | |||||||||
Singh et al., 2021 (India) [6] | 72, M | P. apista | Fever, dyspnea, gastric upset, diarrhea | COVID-19 | MALDI-TOF MS | Susceptible for IPM, MINO, DOXY and ST; Resistant for CAZ, MEPM, PIPC/TAZ, colistin, AMK, CPZ/SBT (Details unknown) | none | IPM | Survived |
Present case | 61, M | P. apista | Fever | Colorectal cancer, renal cell carcinoma, DM | MALDI-TOF MS, 16S rRNA sequencing | See Table 1 | none | ST | Survived |