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Table 1 Demographic and baseline clinical characteristics of patients with CRE infection (n = 189)

From: Molecular epidemiology and outcome of carbapenem-resistant Enterobacterales in Saudi Arabia

Variable n (%) Median (IQR)
Age (years)   62.8 (44.4–73.5)
Gender
 Male 102 (54.0)  
 Female 87 (46.0)  
Baseline Comorbidities
 Heart Disease 38 (20.1)  
 Peripheral vascular disease 9 (4.8)  
 Cerebral vascular accident 37 (19.6)  
 Chronic kidney disease 28 (14.8)  
 End stage renal disease 10 (5.3)  
 HIV 1 (0.5)  
 Dementia 19 (10.1)  
 COPD 6 (3.2)  
 Connective tissue disease 5 (2.7)  
 Peptic ulcer disease 7 (3.7)  
 Mild liver disease 7 (3.7)  
 Moderate and severe liver disease 22 (11.6)  
 Diabetes Mellitus 80 (42.3)  
 Non-hematological malignancy 62 (32.8)  
 Hematological malignancy 11 (5.8)  
 Solid organ transplant 8 (4.2)  
 Bone marrow transplant 4 (2.1)  
Immunosuppressive medication 41 (21.7)  
Charlson comorbiditiy index   6 (3–8)
APACHE II score1   19 (9.0–31.5)
Pitt bacteremia score2   2 (1–6)
Type of CRE infection3
 CLABSI 28 (14.8)  
 HAP/VAP 45 (23.8)  
 Complicated UTI 45 (23.8)  
 Complicated intra-abdominal infection 32 (16.9)  
 Skin and soft tissue infection 20 (10.6)  
 Joint/bone infection 6 (3.2)  
 Primary bacteremia (source unidentified) 15 (7.9)  
 Other 19 (10.1)  
Organism isolates4
 Escherichia coli 21 (11.1)  
 Klebsiella pneumoniae 165 (87.3)  
 Both E. coli and K. pneumoniae 2 (1.1)  
CRE bacteremia 77 (40.7)  
Location at time of CRE culture
 Emergency Room 20 (10.6)  
 Medical Floor 52 (27.5)  
 Surgical Floor 21 (11.1)  
 Hematology/Oncology Floor 29 (15.3)  
 OB/GYN Floor 1 (0.5)  
 ICU 57 (30.2)  
 Other 9 (4.8)  
Molecular typing5
 KPC 1 (0.5)  
 NDM 32 (16.9)  
 IMP 1 (0.5)  
 OXA_48 131 (69.3)  
 None identified 25 (13.2)  
  1. IQR interquartile range, CLABSI central line-associated blood stream infection, HAP hospital-acquired pneumonia, CRE Carbapenem-resistant Enterobacteriaceae
  2. 1For n = 112 patients, 2For n = 110 patients, 3More than one CRE infection type possible
  3. per patient, 4The isolates were identified at the species level following conventional schemes, percentages may total < 100 due to missing values, 5More than one molecular typing possible per patient