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Table 2 Reactions and their perception 14 to 19 days after boost COVID-19 vaccination

From: Reactogenicity after heterologous and homologous COVID-19 prime-boost vaccination regimens: descriptive interim results of a comparative observational cohort study

 

ChAdOx1/ChAdOx1

ChAdOx1/mRNA

mRNA/mRNA

 

(n = 487)

(n = 1943)

(n = 5715)

Proportion of participants with at least one reported reaction

  

 Total

282 (57.9%)

1675 (86.2%)

4338 (75.9%)

  < 1d interval vaccination – registration

131 (57.7%)

604 (84.2%)

2430 (74.9%)

 1–5d interval vaccination – registration

112 (57.4%)

611 (86.1%)

1387 (76.3%)

  > 5d interval vaccination – registration

39 (60.9%)

460 (89.1%)

521 (79.7%)

Perception

ChAdOx1/ChAdOx1

ChAdOx1/mRNA

mRNA/mRNA

 

(n = 282, NA = 2)

(n = 1675)

(n = 4338, NA = 2)

1) Suspected association between reactions and vaccination

  

Strongly disagree

0 (0.0%)

4 (0.2%)

23 (0.5%)

Disagree

7 (2.5%)

10 (0.6%)

89 (2.1%)

Agree

62 (22.1%)

194 (11.6%)

768 (17.7%)

Strongly agree

211 (75.4%)

1467 (87.6%)

3456 (79.7%)

2) Affection by the reactions

   

Strongly disagree

29 (10.4%)

105 (6.3%)

412 (9.5%)

Disagree

75 (26.8%)

276 (16.5%)

1110 (25.6%)

Agree

99 (35.4%)

590 (35.2%)

1501 (34.6%)

Strongly agree

77 (27.5%)

704 (42.0%)

1313 (30.3%)

3) Long-term consequences by the reactions

  

Strongly disagree

233 (83.2%)

1443 (86.1%)

3661 (84.4%)

Disagree

41 (14.6%)

193 (11.5%)

553 (12.8%)

Agree

3 (1.1%)

31 (1.9%)

79 (1.8%)

Strongly agree

3 (1.1%)

8 (0.5%)

43 (1.0%)

  1. Participants with at least one reaction reported 14 to 19 days after boost COVID-19 vaccination (short-term survey) with ChAdOx1 or mRNA vaccine in cohorts of participants with homologous (mRNA/mRNA or ChAdOx1/ChAdOx1) or heterologous (ChAdOx1/mRNA) prime-boost COVID-19 vaccination regimen who completed the short-term survey. ChAdOx1: ChAdOx1 (AstraZeneca). mRNA: BNT162b2 (BioNTech/Pfizer) or mRNA-1273 (Moderna). NA not applicable