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Table 6 Statistically significant latent structure, direct and indirect effects on Mental QOL

From: Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa

Latent variables Estimate STD SE P-value
Serenity → mental QOL 1 0.912   
Despondent → mental QOL 0.788 0.815 0.042 < 0.001
Generally happy → mental QOL 1.027 0.977 0.042 < 0.001
Direct effects
 Sex → alcohol use 0.124 0.118 0.061 0.044
 Sex → adverse events 0.262 0.132 0.203 0.022
 Pill burden → mental QOL − 0.028 − 0.221 0.010 0.010
 Severity of adverse events → mental QOL − 0.111 − 0.155 0.056 0.019
 Adverse events → mental QOL 0.074 0.189 0.035 0.020
 Age → pill burden 0.049 0.161 0.020 0.014
 Treatment → pill burden 0.682 0.118 0.313 0.029
 Sex → pill burden 1.300 0.184 0.402 0.001
 Pill burden → severity of adverse events 0.059 0.356 0.011 < 0.000
Indirect effects
 Age → pill burden → mental QOL − 0.001 − 0.060 0.0009 0.072
 Treatment regimen → pill burden → mental QOL − 0.021 − 0.103 0.012 0.092
 Sex → pill burden → mental QOL − 0.287 − 0.037 0.141 0.041
 Sex → adverse events → mental 0.014 0.025 0.018 0.435
 Pill burden → severity of adverse events → mental − 0.014 − 0.201 0.010 0.215
Correlations
 Number of adverse events ↔ severity of adverse events 0.326 0.539 0.040 < 0.001
 Number of adverse events ↔ pill burden 1.341 0.510 0.209 < 0.001