Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa

Table 6 Statistically significant latent structure, direct and indirect effects on Mental QOL

Latent variables	Estimate	STD	SE	P-value
Serenity → mental QOL	1	0.912
Despondent → mental QOL	0.788	0.815	0.042	< 0.001
Generally happy → mental QOL	1.027	0.977	0.042	< 0.001
Direct effects
Sex → alcohol use	0.124	0.118	0.061	0.044
Sex → adverse events	0.262	0.132	0.203	0.022
Pill burden → mental QOL	− 0.028	− 0.221	0.010	0.010
Severity of adverse events → mental QOL	− 0.111	− 0.155	0.056	0.019
Adverse events → mental QOL	0.074	0.189	0.035	0.020
Age → pill burden	0.049	0.161	0.020	0.014
Treatment → pill burden	0.682	0.118	0.313	0.029
Sex → pill burden	1.300	0.184	0.402	0.001
Pill burden → severity of adverse events	0.059	0.356	0.011	< 0.000
Indirect effects
Age → pill burden → mental QOL	− 0.001	− 0.060	0.0009	0.072
Treatment regimen → pill burden → mental QOL	− 0.021	− 0.103	0.012	0.092
Sex → pill burden → mental QOL	− 0.287	− 0.037	0.141	0.041
Sex → adverse events → mental	0.014	0.025	0.018	0.435
Pill burden → severity of adverse events → mental	− 0.014	− 0.201	0.010	0.215
Correlations
Number of adverse events ↔ severity of adverse events	0.326	0.539	0.040	< 0.001
Number of adverse events ↔ pill burden	1.341	0.510	0.209	< 0.001

ISSN: 1471-2334