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Table 3 Characteristics of patients with prehospital norepinephrine administration (early NE) and patients without prehospital norepinephrine administration (non early NE)

From: Prehospital norepinephrine administration reduces 30-day mortality among septic shock patients

 

Non early NE (n = 335)

Early NE (n = 143)

p value

Demographics

 Age (years)

70 ± 16

67 ± 12

0.066

 Hypertension

145 (43%)

51 (36%)

0.122

 Chronic cardiac failure

74 (22%)

31 (22%)

0.921

 Diabetes mellitus

84 (25%)

45 (31%)

0.150

 Cancer history

118 (35%)

51 (36%)

0.927

 COPD

43 (13%)

27 (19%)

0.089

 Chronic renal failure

53 (16%)

15 (10%)

0.129

Prehospital

 SBP (mmHg)

104 ± 45

84 ± 26

 < 10–3

 DBP (mmHg)

61 ± 19

50 ± 21

 < 10–3

 MAP (mmHg)

74 ± 21

61 ± 22

< 10–3

 HR (beats min−1)

113 ± 28

116 ± 30

0.323

 RR (movements min−1)

30 [22–36]

29 [22–35]

0.964

 Pulse oximetry (%)

92 [85–96]

92 [84–96]

0.225

 Body core temperature (°C)

38.4 [36.9–39.1]

38.0 [36.1–39.1]

0.078

 Glasgow coma scale

15 [13–15]

14 [10–15]

< 10–3

 Blood lactate (mmol l−1)

5.4 ± 3.1

6.7 ± 3.7

0.006

 Fluid expansion (ml)

700 [500–1000]

1000 [750–1500]

< 10–3

 Fluid expansion indexed on body weight (ml kg−1)

12 ± 8

18 ± 10

< 10–3

 Norepinephrine administration

0 (0%)

143 (100%)

–

 Norepinephrine dose (mcg kg−1 min−1)

0.25 [0.13–0.47]

–

–

 Prehospital AB administration

92 (33%)

32 (22%)

0.206

 Prehospital duration (min)

73 ± 29

80 ± 36

0.093

Hospital

 Initial SBP (mmHg)

105 ± 25

104 ± 27

0.761

 Initial DBP (mmHg)

62 ± 18

61 ± 20

0.887

 Initial MBP (mmHg)

76 ± 19

76 ± 22

0.891

 Initial HR (beats min−1)

108 ± 25

104 ± 26

0.067

 Initial RR (movements min−1)

25 [20–32]

22 [17–30]

0.002

 Initial pulse oximetry (%)

97 [94–99]

97 [95–99]

0.303

 Initial body core temperature (°C)

38.0 [36.0–39.0]

36.1 [35.8–39.1]

0.768

 Initial Glasgow coma scale

15 [14–15]

14 [14–15]

0.890

 Initial blood lactate (mmol l−1)

4.0 ± 3.1

5.1 ± 3.9

0.004

 SOFA score

5 [3–9]

8 [5–10]

< 10–3

 SAPS2 score

59 ± 20

63 ± 24

0.091

 In-ICU length of stay (days)

3 [1–8]

6 [3–10]

0.023

 In-hospital length of stay (days)

10 [5–18]

12 [6–21]

0.107

  1. Results were expressed as mean and standard deviation for quantitative parameters (normal distribution), as median and interquartile range for quantitative parameters (non-Gaussian distribution), and as absolute value and percentage for qualitative parameters. The p-value corresponds to the comparison between patients with prehospital norepinephrine administration (early NE) and patients without prehospital norepinephrine administration (non early NE)
  2. SBP systolic blood pressure, DBP diastolic blood pressure, MBP mean blood pressure, HR heart rate, RR respiratory rate, ICU intensive care unit, SOFA sequential organ failure assessment, SAPS2 simplified acute physiology score 2nd version, HIV human immunodeficiency virus, COPD chronic obstructive pulmonary disease, AB antibiotic therapy, min minutes
  3. Values in bold indicate a p-value < 0.05 between living and deceased patients
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BMC Infectious Diseases

ISSN: 1471-2334

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