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Table 1 Population characteristics

From: Prehospital norepinephrine administration reduces 30-day mortality among septic shock patients

 

Overall population (n = 478)

Living (n = 332)

Deceased (n = 146)

p value

Demographics

 Age (years)

69 ± 15

67 ± 15

73 ± 14

2.10–3

 Hypertension

196 (41%)

134 (40%)

62 (42%)

0.937

 Chronic cardiac failure

105 (22%)

52 (16%)

53 (36%)

< 10–3

 Diabetes mellitus

129 (27%)

94 (28%)

35 (24%)

0.120

Cancer history

169 (35%)

104 (31%)

65 (44%)

0.011

 COPD

70 (15%)

45 (14%)

25 (17%)

0.203

 Chronic renal failure

68 (14%)

41 (12%)

27 (18%)

0.082

Prehospital

 SBP (mmHg)

98 ± 41

100 ± 46

94 ± 29

0.095

 DBP (mmHg)

58 ± 20

59 ± 21

55 ± 20

0.058

 MAP (mmHg)

70 ± 22

72 ± 23

68 ± 22

0.112

 HR (beats min−1)

114 ± 29

115 ± 27

112 ± 30

0.375

 RR (movements min−1)

30 [22–36]

28 [31–35]

31 [25–38]

0.043

 Pulse oximetry (%)

92 [85–96]

93 [86–97]

90 [83–95]

0.021

 Body core temperature (°C)

38.3 [36.4–39.1]

38.5 [36.8–39.3]

38.0 [35.8–39.0]

0.007

 Glasgow coma scale

15 [13–15]

15 [13–15]

14 [11–15]

0.010

 Blood lactate (mmol l−1)

5.9 ± 3.4

5.8 ± 3.4

6.3 ± 3.6

0.313

 Fluid expansion (ml)

750 [500–100]

750 [500–1000]

750 [500–1200]

0.464

 Fluid expansion indexed on body weight (ml kg−1)

14 ± 9

14 ± 9

14 ± 9

0.890

 Norepinephrine administration

143 (30%)

99 (30%)

44 (30%)

0.927

 Norepinephrine dose (mg h−1)

1.0 [0.5–2.0]

1.0 [0.5–2.0]

1.3 [1.0–2.0]

0.065

 Prehospital AB administration

124 (26%)

91 (72%)

33 (23%)

0.206

 Prehospital duration (min)

72 ± 34

70 ± 34

74 ± 34

0.291

Hospital

 Initial SBP (mmHg)

105 ± 26

106 ± 26

101 ± 26

0.016

 Initial DBP (mmHg)

62 ± 19

63 ± 19

59 ± 19

0.040

 Initial MBP (mmHg)

76 ± 20

77 ± 19

73 ± 20

0.023

 Initial HR (beats min−1)

107 ± 26

107 ± 24

106 ± 29

0.732

 Initial RR (movements min−1)

25 [19–30]

24 [18–30]

26 [20–35]

0.011

 Initial pulse oximetry (%)

97 [94–99]

97 [95–99]

97 [93–98]

10–3

 Initial body core temperature (°C)

38.0 [36.0–39.0]

39.0 [37.0–39.0]

36.5 [35.0–38.8]

0.009

 Initial Glasgow coma scale

15 [14–15]

15 [14–15]

14 [12–15]

< 10–3

 Initial blood lactate (mmol l−1)

4.3 ± 3.4

3.6 ± 2.9

5.8 ± 3.9

< 10–3

 SOFA score

6 [4–10]

6 [3–9]

8 [5–11]

< 10–3

 SAPS2 score

61 ± 22

55 ± 20

72 ± 21

< 10–3

 In-ICU length of stay (days)

4 [2–8]

5 [2–9]

3 [1–8]

0.009

 In-hospital length of stay (days)

10 [5–18]

14 [8–23]

5 [2–11]

< 10–3

  1. Results were expressed as mean and standard deviation for quantitative parameters (normal distribution), as median and interquartile range for quantitative parameters (non-gaussian distribution), and as absolute value and percentage for qualitative parameters. P-value corresponds to the comparison between deceased and living patients
  2. SBP systolic blood pressure, DBP diastolic blood pressure, MBP mean blood pressure, HR heart rate, RR respiratory rate, ICU intensive care unit, SOFA sequential organ failure assessment, SAPS2 simplified acute physiology score 2nd version, HIV human immunodeficiency virus, COPD chronic obstructive pulmonary disease, AB antibiotic therapy, min minutes
  3. Values in bold indicate a p-value < 0.05 between living and deceased patients
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BMC Infectious Diseases

ISSN: 1471-2334

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