Table 1 Univariate analysis of the baseline characteristics associated with in-hospital mortality of patients with pulmonary tuberculosis
|  | Non-survivor n = 74 | Survivor n = 188 | Crude hazard ratio (95% CI) | P |
|---|---|---|---|---|
Female | 39 (53) | 95 (51) | 1.131 (0.714–1.792) | 0.600 |
Age, years old | 87 (81–90) | 82 (78–88) | 1.062 (1.023–1.102) | 0.002 |
body mass index, kg/m2 | 17.8 (15.7–20.4) | 19.1 (17.4–21.2) | 0.931 (0.867–1.000) | 0.052 |
Performance status | 4 (3–4) | 2 (1–3) | 3.007 (2.145–4.217) | < 0.001 |
Smoker | 15 (20) | 32 (17) | 1.049 (0.594–1.855) | 0.869 |
COPD | 7(9) | 14 (7) | 1.103 (0.500–2.433) | 0.808 |
Heart failure | 22 (30) | 26 (14) | 1.706 (1.033–2.816) | 0.037 |
Cerebrovascular disease | 14 (19) | 30 (16) | 1.392 (0.776–2.497) | 0.267 |
Diabetes mellitus | 21 (28) | 45 (24) | 1.200 (0.722–1.993) | 0.481 |
Chronic kidney disease | 17 (23) | 18 (10) | 2.817 (1.624–4.888) | < 0.001 |
Hepatic diseases | 11 (15) | 8 (4) | 2.551 (1.341–4.852) | 0.004 |
Respiratory failure | 46 (62) | 39 (21) | 3.525 (2.196–5.659) | < 0.001 |
Smear grade > 2+ | 12 (16) | 30 (16) | 0.632 (0.330–1.208) | 0.165 |
Resistance to first-line drug | 2 (3) | 14 (7) | 0.397 (0.097–1.619) | 0.198 |
Standard therapy | 25 (34) | 117 (62) | 0.373 (0.230–0.605) | < 0.001 |
Conversion | 36 (49) | 184 (98) | 0.120 (0.075–0.190) | < 0.001 |
Conversion within 60 days | 33 (45) | 147 (78) | 0.594 (0.359–0.983) | 0.043 |
Conversion within 90 days | 35 (47) | 175 (93) | 0.218 (0.136–0.349) | < 0.001 |
Conversion within 120 days | 36 (49) | 183 (97) | 0.132 (0.083–0.209) | < 0.001 |
Average interval of sputum culture (week) | 2 (1.5–2) | 2 (1.5–2) | 1.024 (0.666–1.577) | 0.912 |
WBC (×103/µL) | 6.7 (4.7–10.2) | 6.5 (5.2–8.1) | 1.028 (0.956–1.106) | 0.456 |
 C-reactive protein (mg/dL) | 6.5 (3.4–11.7) | 2.6 (0.7–6.4) | 1.046 (1.019–1.073) | 0.001 |
Hemoglobin (g/dL) | 10.3 (9.1–11.4) | 11.5 (10.2–12.9) | 0.702 (0.619–0.796) | < 0.001 |
Albumin (g/dL) | 2.1 (1.7–2.5) | 3.0 (2.5–3.5) | 0.174 (0.111–0.273) | < 0.001 |
AST (IU/L) | 28 (22–44) | 25 (20–35) | 1.005 (1.003–1.008) | < 0.001 |
ALT (IU/L) | 18 (12–29) | 16 (11–25) | 1.007 (1.004–1.010) | < 0.001 |
BUN (mg/dL) | 26.0 (16.8–39.0) | 16.5 (12.6–21.2) | 1.035 (1.025–1.046) | < 0.001 |
Creatinine (mg/dL) | 0.78 (0.45–1.15) | 0.73 (0.56–0.89) | 1.666 (1.322–2.100) | < 0.001 |
Number of lobes | 4 (3–5) | 3 (2–4) | 1.226 (1.037–1.449) | 0.017 |
Cavity | 31 (42) | 71 (38) | 0.876 (0.550–1.397) | 0.579 |
Bilateral shadow | 56 (76) | 127 (68) | 1.330 (0.781–2.265) | 0.294 |
Pleural effusion | 36 (49) | 70 (37) | 1.503 (0.950–2.380) | 0.082 |