Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines

Otani, Kanako; Saito, Mayuko; Okamoto, Michiko; Tamaki, Raita; Saito-Obata, Mariko; Kamigaki, Taro; Lirio, Irene C.; Segubre-Mercado, Edelwisa; Tallo, Veronica; Lupisan, Socorro; Oshitani, Hitoshi

doi:10.1186/s12879-022-07289-3

BMC Infectious Diseases

Table 3 Incidence rates of virus-specific LRTIs per 100 child-years and IRRs for severe LRTI compared to non-severe LRTI in Biliran, Philippines, from March 2014 to June 2016

From: Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines

Detected virus	LRTI classification	0–5 months					6–11 months					12–23 months
Detected virus	LRTI classification	n	IR	[95%CI]	IRR	[95%CI]	n	IR	[95%CI]	IRR	[95%CI]	n	IR	[95%CI]	IRR	[95%CI]
AdV	Non-severe	0	0.0	[0.0–2.1]	1		2	1.4	[0.2–5.0]	1		1	0.7	[0.0–3.7]	1
	Severe	0	0.0	[0.0–2.1]	0.00	[0.00–0.00]	0	0.0	[0.0–2.5]	0.00	[0.00–5.32]	0	0.0	[0.0–2.4]	0.00	[0.00–39.00]
	Total	0	0.0	[0.0–2.1]	–	–	2	1.4	[0.2–5.0]	–	–	1	0.7	[0.0–3.7]	–	–
RV	Non-severe	24	13.7	[8.8–20.4]	1		13	8.9	[4.8–15.3]	1		22	14.5	[9.1–21.9]	1
	Severe	15	8.6	[4.8–14.1]	0.63	[0.30–1.24]	7	4.8	[1.9–9.9]	0.54	[0.18–1.45]	4	2.6	[0.7–6.7]	0.18	[0.05–0.54]
	Total	39	22.3	[15.8–30.4]	–	–	21	14.4	[8.9–22.0]	-	-	27	17.7	[11.7–25.8]	–	–
EV	Non-severe	1	0.6	[0.0–3.2]	1		2	1.4	[0.2–5.0]	1		3	2.0	[0.4–5.8]	1
	Severe	2	1.1	[0.1–4.1]	2.00	[0.10–117.99]	1	0.7	[0.0–0.0]	0.50	[0.01–9.60]	1	0.7	[0.0–3.7]	0.33	[0.01–4.15]
	Total	3	1.7	[0.4–5.0]	–	–	3	2.1	[0.4–6.0]	-	-	4	2.6	[0.7–6.7]	–	–
RSV	Non-severe	15	8.6	[4.8–14.1]	1		3	2.1	[0.4–6.0]	1		12	7.9	[4.1–13.8]	1
	Severe	11	6.3	[3.1–11.2]	0.73	[0.30–1.71]	7	4.8	[1.9–9.9]	2.33	[0.53–13.98]	5	3.3	[1.1–7.7]	0.42	[0.11–1.27]
	Total	27	15.4	[10.2–22.4]	–	–	11	7.6	[3.8–13.5]	–	–	18	11.8	[7.0–18.7]	–	–
MPV	Non-severe	1	0.6	[0.0–3.2]	1		1	0.7	[0.0–3.8]	1		4	2.6	[0.7–6.7]	1
	Severe	1	0.6	[0.0–3.2]	1.00	[0.01–78.50]	0	0.0	[0.0–2.5]	0.00	[0.00–39.00]	2	1.3	[0.2–4.7]	0.50	[0.05–3.49]
	Total	2	1.1	[0.1–4.1]	–	–	1	0.7	[0.0–3.8]	–	–	6	3.9	[1.5–8.6]	–	–
PIV	Non-severe	4	2.3	[0.6–5.8]	1		7	4.8	[1.9–9.9]	1		11	7.2	[3.6–12.9]	1
	Severe	2	1.1	[0.1–4.1]	0.50	[0.05–3.49]	4	2.7	[0.7–7.0]	0.57	[0.12–2.25]	0	0.0	[0.0–2.4]	0.00	[0.00–0.40]
	Total	6	3.4	[1.37.5]	–	–	11	7.6	[3.8–13.5]	–	–	11	7.2	[3.6–12.9]	–	–
IFV	Non-severe	3	1.7	[0.4–5.0]	1		4	2.7	[0.7–7.0]	1		4	2.6	[0.7–6.7]	1
	Severe	1	0.6	[0.0–3.2]	0.33	[0.01–4.15]	3	2.1	[0.4–6.0]	0.75	[0.11–4.43]	3	2.0	[0.4–5.8]	0.75	[0.11–4.43]
	Total	5	2.9	[0.9–6.7]	–	–	7	4.8	[1.9–9.9]	–	–	7	4.6	[1.9–9.5]	–	–
Co-detection	Non-severe	7	4.0	[1.6–8.2]	1		3	2.1	[0.4–6.0]	1		1	0.7	[0.0–3.7]	1
Co-detection	Severe	2	1.1	[0.1–4.1]	0.29	[0.03–1.50]	1	0.7	[0.0–3.8]	0.33	[0.01–4.15]	1	0.7	[0.0–3.7]	1.00	[0.01–78.50]
	Total	9	5.1	[2.4–9.8]	–	–	4	2.7	[0.8–7.0]	–	–	3	2.0	[0.4–5.8]	–	–
Negative	Non-severe	20	11.4	[7.0–17.6]	1		20	13.7	[8.4–21.2]	1		28	18.4	[12.2–26.6]	1
	Severe	11	6.3	[3.1–11.2]	0.55	[0.24–1.20]	13	8.9	[4.8–15.3]	0.65	[0.30–1.37]	7	4.6	[1.8–9.5]	0.25	[0.09–0.59]
	Total	31	17.7	[12.0–25.1]	–	–	34	23.3	[16.2–32.6]	–	–	36	23.7	[16.6–32.8]	–	–
Total	Non-severe	75	42.8	[33.7–53.7]	1		55	37.8	[28.4–49.1]	1		86	56.5	[45.2–69.8]	1
	Severe	45	25.7	[18.7–34.4]	0.61	[0.41–0.88]	36	24.7	[17.3–34.2]	0.65	[0.42–1.01]	23	15.1	[9.6–22.7]	0.27	[0.16–0.43]
	Total	122	69.6	[57.8–83.2]	–	–	94	64.5	[52.1–79.0]	–	–	113	74.3	[61.2–89.3]	–	–

Total LTRTI included non-severe LRTI, severe LRTI and undefined LRTI. Observed child-years were 175.2, 145.7, and 152.2 at age 0–5, 6–11, and 12–23 months, respectively. Episodes in which samples were not tested for virus detection were excluded (n = 21)
IR, incidence rate; IRR, incidence rate ratio; LRTI, lower respiratory tract infection; 95%CI, 95% confidence interval; AdV, Adenovirus; RV, Rhinovirus; EV, Enterovirus; RSV, Respiratory syncytial virus; MPV, Human metapneumovirus; PIV, Parainfluenza virus; IFV, Influenza virus

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