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Table 3 Logistic regression models of CD4 count < 500 cells/mm3

From: The relationship of hair glucocorticoid levels to immunological and virological outcomes in a large cohort of combination antiretroviral therapy treated people living with HIV

 

n (%)

Univariate

Multivariate

p

cOR (95% CI)

p

aOR(95% CI)

Hair cortisol

 First quartile

146 (49.0%)

1 [reference]

–

1 [reference]

–

 Second quartile

157 (52.7%)

1.18 (0.85–1.62)

0.326

1.14 (0.82–1.60)

0.444

 Third quartile

166 (55.7%)

1.33 (0.96–1.83)

0.085

1.10 (0.78–1.55)

0.596

 Fourth quartile

186 (62.6%)

1.77 (1.28–2.45)

< 0.001

1.41 (0.99–2.00)

0.055

Age

 18–30

–

–

–

1 [reference]

–

 31–40

–

–

–

1.08 (0.74–1.58)

0.684

 41–50

–

–

–

1.87(1.21–2.88)

0.005

 51–60

–

–

–

2.05(1.26–3.32)

0.004

Gender

–

–

–

0.65 (0.47–0.90)

0.009

Ethnicity

–

–

–

0.72 (0.56–0.93)

0.01

Marital status

–

–

–

0.99 (0.76–1.30)

0.961

Education levels

–

–

–

0.59 (0.45–0.78)

 < .001

Employment status

–

–

–

0.91 (0.66–1.25)

0.547

Monthly income levels

–

–

–

0.98 (0.76–1.27)

0.874

BMI

–

–

–

0.95 (0.91–0.99)

0.017

Smoking

–

–

–

0.87 (0.65–1.18)

0.369

Drinking

–

–

–

0.83 (0.63–1.09)

0.172

Frequency of hair washing

–

–

–

0.84 (0.57–1.24)

0.381

Years of HIV diagnosis

–

–

–

0.90(0.81–0.97)

0.01

cART status

–

–

–

1.08 (0.79–1.47)

0.627

Years of cART

–

–

–

1.04 (0.95–1.14)

0.408

Self-reported adherence

–

–

–

1.26 (0.79–2.01)

0.323

HIV viral load

–

–

–

2.03 (0.93–4.42)

0.076

Hair cortisone

 First quartile

132 (44.4%)

1 [reference]

–

1 [reference]

–

 Second quartile

162 (54.2%)

1.48 (1.07–2.04)

0.018

1.52 (1.09–2.13)

0.014

 Third quartile

165 (55.4%)

1.55 (1.12–2.14)

0.008

1.50 (1.07–2.12)

0.020

 Fourth quartile

195 (65.7%)

2.39 (1.72–3.33)

< 0.001

2.15 (1.51–3.05)

< 0.001

Age

 18–30

–

–

–

1 [reference]

–

 31–40

–

–

–

1.10 (0.75–1.61)

0.631

 41–50

–

–

–

1.83(1.18–2.82)

0.007

 51–60

–

–

–

1.98(1.21–3.23)

0.006

Gender

–

–

–

0.62 (0.45–0.85)

0.003

Ethnicity

–

–

–

0.73 (0.57–0.94)

0.016

Marital status

–

–

–

1.00 (0.77–1.31)

0.992

Education levels

–

–

–

0.61 (0.46–0.80)

 < .001

Employment status

–

–

–

0.89 (0.64–1.23)

0.469

Monthly income levels

–

–

–

1.01 (0.78–1.31)

0.934

BMI

–

–

–

0.95 (0.91–0.99)

0.009

Smoking

–

–

–

0.85 (0.63–1.15)

0.287

Drinking

–

–

–

0.85 (0.65–1.12)

0.244

Frequency of hair washing

–

–

–

0.84 (0.57–1.24)

0.37

Years of HIV diagnosis

–

–

–

0.88 (0.81–0.96)

0.006

cART status

–

–

–

1.10 (0.80–0.96)

0.554

Years of cART

–

–

–

1.04 (0.95–1.14)

0.403

Self-reported adherence

–

–

–

1.25 (0.78–2.00)

0.349

HIV viral load

–

–

–

2.11 (0.96–4.63)

0.063

  1. CI confidence interval, cOR crude odds ratio, aOR adjusted odds ratio, Adjusted for age, gender, ethnicity, marital status, education level, employment status, monthly income levels, BMI, smoking, drinking, frequency of hair washing, years of HIV diagnosis, cART status, years of cART, self-reported adherence, and HIV viral load in the multivariate model