Table 2 Study population demographic characteristics at baseline for the ATLAS, FLAIR, pooled ATLAS/FLAIR and ATLAS-2M trials
ATLAS-2M [15] | Statistical comparison | ||||
|---|---|---|---|---|---|
SoC (n = 591) | CAB + RPV Q4W (n = 591) | CAB + RPV Q4Wa (n = 327) | CAB + RPV Q8Wa (n = 327) | ATLAS/FLAIR vs ATLAS-2M CAB + RPV Q4W | |
Age (years), median (range) | 38 (18, 82) | 38 (19, 74) | 42 (19, 67) | 41 (20, 83) | P = 0.0002b |
Male, n (%) | 423 (72) | 429 (73) | 252 (77) | 254 (78) | P = 0.1563c |
Race, n (%) | P = 0.0955d | ||||
White | 408 (69) | 430 (73) | 256 (78) | 238 (73) | |
Black/African American | 133 (23) | 109 (18) | 45 (14) | 57 (17) | |
Asian | 28 (5) | 34 (6) | 12 (4) | 17 (5) | |
Other | 20 (3) | 18 (3) | 14 (4) | 15 (5) | |
Ethnicity | |||||
Hispanic/Latino, n (%) | 74 (13) | 63 (11) | 42 (13) | 54 (17) | P = 0.3309c |
BMI (kg/m2), mean (SD) | 25.9 (5.4) | 25.7 (4.8) | 26.2 (5.2) | 26.2 (5.1) | P = 0.1451b |
CD4-cell count (cells/mm2), mean (SD) | 670.2 (273.2) | 672.7 (264.3) | 741.0 (288.8) | 688.6 (266.0) | P = 0.0004b |
CD4-cell count (cells/mm2), n (%) | P = 0.0526d | ||||
< 350 | 54 (9) | 42 (7) | 17 (5) | 25 (8) | |
≥ 350 to < 500 | 117 (20) | 120 (20) | 49 (15) | 60 (18) | |
≥ 500 | 420 (71) | 429 (73) | 261 (80) | 242 (74) | |
Baseline third active class, n (%) | |||||
INSTI | 382 (65) | 385 (65) | 141 (43) | 136 (42) | P < 0.0001d |
NNRTI | 155 (26) | 155 (26) | 156 (48) | 151 (46) | |
PI | 54 (9) | 51 (9) | 30 (9) | 40 (12) | – |