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Table 3 One-month and 1-year mortality rate, univariate and multivariate analyses of the risk of death (Hazard Ratio) depending on presence of bacteraemia, age group, sex, qSOFA score, renal function and natremia

From: Bacteraemia and quick Sepsis Related Organ Failure Assessment (qSOFA) are independent risk factors for long-term mortality in very elderly patients with suspected infection: retrospective cohort study

Variable

Follow-up length, daysa

Mortality Rateb

95% CI

Crude analysis

Multivariable analysis

HR

95% CI

p value

Adjusted HR

95% CI

p value

One-month follow-up

 Exposure

  Bacteraemia

23.36

3.08

(2.47–3.85)

1.53

(1.07–2.20)

0.021*

1.30

(0.90–1.88)

0.16

  Controls

24.77

1.97

(1.26–2.24)

Ref

Ref

 Age group

  ≥ 90 years

10.50

3.71

(2.59–4.88)

1.66

(1.14–2.44)

0.009*

1.49

(1.01–2.19)

0.044*

  80–89 years

37.63

2.17

(1.71–2.65)

Ref

Ref

 Gender

  Men

21.35

2.90

(2.18–3.63)

1.29

(0.91–1.85)

0.15

   

  Women

26.77

2.20

(1.63–2.74)

Ref

 

 qSOFA

  ≥ 2

6.35

8.34

(6.10–10.59)

4.60

(3.21–6.60)

 < 0.001*

3.87

(2.64–5.78)

 < 0.001*

  < 2

41.78

1.62

(1.24–2.01)

Ref

Ref

 Kidney injury*

  Yes

33.56

2.74

(2.18–3.30)

1.36

(9.00–2.07)

0.096

   

  No

14.57

1.99

(1.27–2.71)

Ref

 

 Sodium

  > 145 mmol/L

3.38

7.08

(4.25–9.92)

2.97

(1.90–4.65)

 < 0.001*

1.76

(1.09–2.83)

0.019*

  ≤ 145 mmol/L

44.74

2.16

(1.74–2.60)

Ref

Ref

One-year follow-up

 Exposure

  Bacteraemia

218.93

0.69

(0.58–0.80)

1.42

(1.12–1.81)

0.004*

1.31

(1.03–1.67)

0.029*

  Controls

249.37

0.46

(0.39–0.56)

Ref

Ref

 Age group

  ≥ 90 years

96.23

0.83

(0.65–1.01)

1.56

(1.20–2.03)

0.001*

1.53

(1.17–1.99)

0.002*

  80–89 years

372.04

0.51

(0.44–0.58)

Ref

Ref

 Gender

  Men

203.24

0.65

(0.53–0.76)

1.21

(0.95–1.53)

0.12

   

  Women

265.02

0.52

(0.43–0.61)

Ref

 

 qSOFA

  ≥ 2

49.48

1.60

(1.24–1.95)

2.98

(2.98–3.88)

 < 0.001*

2.71

(2.05–3.57)

 < 0.001*

  < 2

418.78

0.81

(0.71–0.94)

Ref

Ref

 Kidney injury*

  Yes

327.64

1.27

(1.10–1.46)

1.20

(0.91–1.57)

0.19

   

  No

140.62

2.58

(2.04–3.25)

Ref

 

 Sodium

  > 145 mmol/L

29.81

1.14

(0.76–1.52)

1.94

(1.35–2.78)

 < 0.001*

1.37

(0.94–1.99)

0.10

  ≤ 145 mmol/L

438.45

0.54

(0.47–0.60)

Ref

Ref

  1. CI confidence interval
  2. *Kidney injury is estimated glomerular filtration rate < 60 mL/min HR: hazard Ratio. qSOFA: quick Systematic Organ Failure Assessment. eGFR: estimated glomerular filtration rate. aMeasured in person years. bRate per 1 person-year
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BMC Infectious Diseases

ISSN: 1471-2334

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