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Table 3 Risk factors for the acquisition of secondary infection

From: Secondary infection in COVID-19 critically ill patients: a retrospective single-center evaluation

Risk factors

n = 94

Odds ratio (95% CI)

P value

Demographics

   

Age (years)—median [IQR]2

70 (62–77)

0.96 (0.92–1.01)

0.13

Male gender—no. (%)

55 (59%)

0.41 (0.17–0.99)

0.05

BMI—median [IQR]2

27.5 (24.2–30.8)

1.007 (0.926–1.095)

0.87

Diabetes mellitus—no. (%)

32 (34%)

0.37 (0.15–0.91)

0.03

Hypertension—no. (%)

58 (62%)

0.48 (0.19–1.24)

0.13

Smoking—no. (%)

4 (4%)

1.12 (0.13–9.93)

0.92

Characteristics of type and severity of illness

   

APACHE IV score—median [IQR]2

46 (35–57)

0.99 (0.96–1.02)

0.35

SOFA score on admission—median [IQR]2

3 (2–5)

1.14 (0.96–1.35)

0.13

Hemodynamic assist device—no. (%)

4 (4%)

4.54 (0.17–122.37)

0.37

Treatment

   

Corticosteroids dose—median [IQR]2

0 (0–384)

1.004 (1.001–1.007)

0.004

Other immunosuppressive therapies*—no. (%)

7 (7%)

0.59 (0.12–2.78)

0.50

  1. *Other immunosuppressive therapies included: infliximab, ruxolitinib, bortezomib, mycophenolate mofetil, azacitidine and azathioprine
  2. *p < 0.05