Table 2 Severity of adverse reactions after the first and second vaccinations
Severity | Grade 0 | Grade 1 | Grade 2 | Grade 3 | p value |
|---|---|---|---|---|---|
First dose/second dose | First dose/second dose | First dose/second dose | First dose/second dose | ||
n (%) | n (%) | n (%) | n (%) | Â | |
Injection site reaction | 102 (22.3)/168 (36.7) | 231 (50.4)/190 (41.5) | 118 (25.8)/95 (20.7) | 7 (1.5)/5 (1.1) | < 0.01 |
Fatigue | 287 (62.7)/201 (43.9) | 120 (26.2)/90 (19.7) | 46 (10.0)/139(30.3) | 5 (1.1)/28 (6.1) | < 0.01 |
Chills | 447 (97.6)/389 (84.9) | 9 (2.0)/48 (10.5) | 2 (0.4)/21 (4.6) | 0/0 | < 0.01 |
Fever | 446 (97.4)/346 (75.5) | 12 (2.6)/102 (22.3) | 0/10 (2.2) | 0/0 | < 0.01 |
Arthralgia | 339 (87.1)/318 (69.4) | 39 (8.5)/67 (14.6) | 16 (3.5)/61 (13.3) | 4 (0.9)/12 (2.6) |  < 0.01 |
Myalgia | 391 (85.4)/361 (78.8) | 39 (8.5)/48 (10.5) | 25 (5.5)/41 (9.0) | 3 (0.7)/8 (1.7) | 0.04 |
Headache | 366 (79.9)/266 (58.1) | 52 (11.4)/79 (17.2) | 36 (7.9)/90 (19.7) | 4 (0.9)/23 (5.0) | < 0.01 |
Diarrhea | 455 (97.2)/439 (95.9) | 11 (2.4)/16 (3.5) | 0/2 (0.4) | 2 (0.4)/1 (0.2) | 0.35 |
Nausea | 433 (94.5)/407 (88.9) | 18 (3.9)/23 (5.0) | 7 (1.5)/27 (5.9) | 0/1 (0.2) | < 0.01 |
Vomiting | 453 (98.9)/447 (97.6) | 3 (0.7)/9 (2.0) | 2 (0.4)/1 (0.2) | 0/1 (0.2) | 0.22 |