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Table 3 Laboratory Findings of IM patients with normal and elevated ALT

From: Adenosine deaminase as a marker for the severity of infectious mononucleosis secondary to EBV in children

Parameters

IM1 group (n = 54)

IM2 group (n = 50)

Controls (n = 50)

P

WBC (×109/L)

15.3 (11.4–19.5)ab

17.2 (12.8–23.3)a

13.7 (9.3–19.3)b

0.037

Lymphocyte count(×109/L)

10.4 (6.4–12.7)a

11.8 (7.4–16.1)a

3.4 (2.3–5.2)b

< 0.01

Plasma EBV-DNA lg(copies/ml)

3.7 ± 0.6a

4.1 ± 0.7b

0.003

ADA (U/L)

45.1 (38.9–49.4)a

62.3 (53.4–79.3)b

20.1 (17.1–23.8)c

< 0.01

IgA (g/L)

1.3 (1.0–1.8) a

1.5 (1.0–2.0)a

0.8 (0.5–1.2)b

< 0.01

IgG (g/L)

10.4 ± 2.5a

12.2 ± 2.8b

7.7 ± 2.2c

< 0.05

IgM (g/L)

1.4 (1.1–2.0)a

1.8 (1.4–2.2)a

1.1 (0.8–1.6)b

< 0.01

CD3+ (%)

78.1 (71.0–82.8)a

79.4 (75.0–82.7)a

63.8 (54.1–71.8)b

< 0.01

CD3+ CD4+ (%)

19.1 (14.5–23.3)a

15.6 (12.6–20.6)a

32.1 (24.8–39.2)b

< 0,01

CD3+ CD8+ (%)

51.6 ± 10.1a

56.3 ± 11.4b

25.0 ± 8.0c

< 0.05

CD4+/CD8+

0.4 (0.3–0.5)a

0.3 (0.2–0.4)a

1.2 (1.0–1.7)b

< 0.01

CD3-CD(16 + 56)+(%)

11.8 (7.7–16.9)

11.9 (9.0–17.0)

11.1 (6.7–16.1)

0.830

CD3-CD19+ (%)

8.1 (5.4–11.8)a

7.1 (4.4–9.4)a

20.9(16.0–29.8)b

< 0.01

CD19 + CD23+ (%)

4.4 (2.4–6.4)a

3.5 (2.4–6.1)a

9.9 (6.8–12.7)b

< 0.01

  1. The data presented as median [interquartile range], mean ± standard deviation and n (%). The univariate analyses were performed using Kruskal-Wallis test for skewed distribution variables, and ANOVA for normal distribution variables. IM1 group represents the normal ALT group, IM2 group represents elevated ALT group. WBC, white blood cell; ADA, denosine deaminase; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M. P< 0.05 between a, b and c